Palladium-Catalyzed Enantioselective Dearomative Domino Heck/Stille Reaction of Indoles
Abstract Palladium-catalyzed enantioselective dearomative difunctionalization of N-substituted indoles was developed via dearomative carbonpalladation and subsequent capture of benzyl-Pd species by organostannane reagents (domino Heck/Stille reaction). A wide range of 2,3-disubstituted chiral indolines bearing vicinal quaternary and tertiary stereocenters was efficiently synthesized in one step with excellent enantioselectivities and diastereoselectivities.
Authors
- Lu Chuan-Jun
- Yi‐Xia Jia (ORCID: https://orcid.org/0000-0001-7936-0049)
- Ren‐Xiao Liang (ORCID: https://orcid.org/0000-0003-0931-1975)
- Bingbing Huang (ORCID: https://orcid.org/0000-0002-7036-2635)
- Renrong Liu (ORCID: https://orcid.org/0000-0002-6474-3909)
- Fei Xie
Institutions
- Qingdao University (CN)
- Tianjin University of Technology (CN)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-10-06
- DOI
- https://doi.org/10.1021/acs.orglett.6c03404
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00