Global Scientometric Mapping of Research Linking the Enteric Nervous System and Oxidative Stress

Background/Objectives: The enteric nervous system (ENS) is essential for gastrointestinal homeostasis and is vulnerable to oxidative imbalance associated with inflammatory, metabolic, and neurodegenerative disorders. However, research linking the ENS and oxidative stress has not been comprehensively mapped. This study characterized the temporal evolution, productivity patterns, collaboration networks, geographical distribution, and thematic structure of this field. Methods: Original research articles were retrieved from the Web of Science Core Collection, Scopus, and PubMed from database inception to 12 September 2026. Records were merged, deduplicated, screened, and harmonized before analysis. Bibliometrix/Biblioshiny and VOSviewer were used to assess annual production, Lotka’s and Bradford’s laws, author and journal productivity, collaboration networks, keyword co-occurrence, trend topics, thematic evolution, and thematic mapping. Results: A total of 251 original articles published between 1989 and 2026 were included. Scientific production showed an annual growth rate of 6.95%, with peaks in 2016 and 2021. Author productivity followed a Lotka-type distribution, and journal dispersion was compatible with Bradford’s law. Brazil had the largest number of corresponding-author publications, followed by the United States and China. Keyword analyses identified recurrent themes involving diabetes mellitus, inflammation, enteric glial cells, Parkinson’s disease, antioxidant mechanisms, neuroprotection, and aging. Temporal analyses indicated increasing integration of neurodegenerative, glial, and gut–brain-related topics. Conclusions: Research linking the ENS and oxidative stress has expanded and diversified over time. The field combines established metabolic and redox-oriented research with increasing attention to inflammatory, neurodegenerative, glial, and gut–brain perspectives within heterogeneous international collaboration networks.