AI and the PI: Infinite Generation, Finite Understanding

Abstract Generative artificial intelligence (AI) produces code and prose quickly, apparently enabling a principal investigator (PI) in a computational group to do more. Assessing this gain must also account for the laboratory’s role in training scientists who understand, maintain, and own their work. AI creates a generation–verification asymmetry: it reduces the effort of producing plausible code and prose without similarly reducing the expertise needed to evaluate them, potentially leaving groups with technical and epistemic debt while obscuring the reasoning needed for supervision. I argue that AI adoption should therefore be judged by whether it builds sustainable laboratory capacity, with assistance adjusted to task purpose and verifiability and human ownership retained for every consequential artifact.

Authors

Publication Details

Journal
Journal of Chemical Information and Modeling
Published
2026-10-06
DOI
https://doi.org/10.1021/acs.jcim.6c03139
Primary Topic
Ethics and Social Impacts of AI
Type
article
Field-Weighted Citation Impact
0.00
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article

AI and the PI: Infinite Generation, Finite Understanding

Toni Giorgino
Journal of Chemical Information and Modeling
Ethics and Social Impacts of AI
article

AI and the PI: Infinite Generation, Finite Understanding

Toni Giorgino
article en

Abstract

Abstract Generative artificial intelligence (AI) produces code and prose quickly, apparently enabling a principal investigator (PI) in a computational group to do more. Assessing this gain must also account for the laboratory’s role in training scientists who understand, maintain, and own their work. AI creates a generation–verification asymmetry: it reduces the effort of producing plausible code and prose without similarly reducing the expertise needed to evaluate them, potentially leaving groups with technical and epistemic debt while obscuring the reasoning needed for supervision. I argue that AI adoption should therefore be judged by whether it builds sustainable laboratory capacity, with assistance adjusted to task purpose and verifiability and human ownership retained for every consequential artifact.

Journal of Chemical Information and Modeling
Openalex Percentile: Top 7%
Ethics and Social Impacts of AI
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