Ru(II)-Catalyzed C–H/O–H Annulation of Benzoic Acids with Trifluoromethyl-Imidoyl Sulfoxonium Ylides: Rapid Synthesis of Dihydroisocoumarin Scaffolds
Abstract A novel ruthenium-catalyzed C–H activation/cyclization reaction of benzoic acid with trifluoromethyl-imidoyl sulfoxonium ylides has been developed for the first time, enabling the rapid synthesis of various trifluoromethyl-functionalized 3,3-disubstituted isocoumarin derivatives in ten minutes with moderate to good yields. This practical methodology with mild reaction conditions exhibits broad scope of substrates, good regioselectivity and high efficiency.
Authors
- Chun Cai (ORCID: https://orcid.org/0000-0002-5755-9361)
- Yang Li
Institutions
- Nanjing University of Science and Technology (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-10-06
- DOI
- https://doi.org/10.1021/acs.joc.6c01708
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00