From emergence to exposure: one health attribution of azole-resistant Aspergillus fumigatus in Southeast Asia
Southeast Asia is a hotspot for azole-resistant Aspergillus fumigatus yet remains underrepresented in global surveillance. Disciplinary approaches, including genomics, environmental sampling, and social science, have progressed but remain poorly integrated. We outline a One Health attribution framework linking selection pressures, environmental reservoirs, exposure pathways, and clinical resistance signals to prioritise surveillance, target interventions, and allocate resources where they will have greatest impact.
Authors
- Sébastien Imbert (ORCID: https://orcid.org/0000-0003-4187-0806)
- Andrew M. Merchant (ORCID: https://orcid.org/0000-0001-8979-6786)
- Michael A. Kertesz (ORCID: https://orcid.org/0000-0003-2112-4451)
- Johanna L. Rhodes (ORCID: https://orcid.org/0000-0002-1338-7860)
- Retno Wahyuningsih (ORCID: https://orcid.org/0000-0002-3294-5792)
- Justin Beardsley (ORCID: https://orcid.org/0000-0003-1978-1559)
- Victoria Brookes (ORCID: https://orcid.org/0000-0003-0963-4926)
- Cuong Nguyen
- Tra My Nu Duong
- Nicola Haggerty Mayers
- Jamie Cross
Institutions
- Universitas Kristen Indonesia (ID)
- The University of Sydney (AU)
- Hanoi Medical University (VN)
- Dharmais Cancer Hospital (ID)
- Centre de Recherche Cardio-Thoracique de Bordeaux (FR)
- University of Glasgow (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- npj Fungal Science
- Published
- 2026-10-06
- DOI
- https://doi.org/10.1038/s44512-026-00004-1
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00