The Relationship Between Vitamin D Level and Cardiovascular Parameters in Women with Polycystic Ovary Syndrome

Background & Objective: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder among women of reproductive age, often associated with metabolic complications. Vitamin D deficiency is frequently observed in PCOS women and is associated with multiple effects. This study was conducted with aim to investigate the association between vitamin D levels and cardiovascular parameters in PCOS women.Materials & Methods: This cross-sectional study was conducted on 371 women aged 18 to 45 years with PCOS who visited the outpatient clinic of Al-Zahra Hospital in Rasht, Iran, 2023. Anthropometric measurements, blood pressure, and biochemical parameters, including vitamin D, lipid profiles, and Fasting Blood Sugar (FBS), were assessed. Participants were classified into two groups of with and without Vitamin D3 deficiency. Individuals with Vitamin D3 levels below 20 ng/dL were categorized as deficient, while those with levels equal to or above 20 ng/dL were considered non-deficient. The two groups were compared and the collected data were analyzed by SPSS software (version 26). P<0.05 was considered significant.Results: The mean age of patients was 32.75±5.54 years. Women with Vitamin D3 deficiency had significantly lower Body Mass Index (BMI) (P=0.015), smaller waist circumference, and higher LDL levels compared to non-deficient women. Logistic regression revealed that LDL levels were independently associated with vitamin D deficiency (OR 1.04, 95% CI 1.02-1.06, P<0.001).Conclusion: Vitamin D deficiency in PCOS women is associated with adverse lipid profiles, particularly elevated LDL levels. Addressing vitamin D deficiency through supplementation could reduce cardiovascular risks and improve metabolic health.