Chronic Inhalation of Sulphureous Water Mitigates Early Amyloid Pathology and Associated Microglial Changes in 5XFAD Mice
Background: Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive decline and behavioral impairments. Hydrogen sulfide (H2S) is an endogenous gasotransmitter that exerts pleiotropic neuromodulatory, anti-inflammatory, cytoprotective, and trophic effects within the central nervous system.
Authors
- Alessandra Ottani (ORCID: https://orcid.org/0000-0002-1676-051X)
- Eleonora Daini (ORCID: https://orcid.org/0000-0002-4020-1179)
- Antonietta Vilella (ORCID: https://orcid.org/0000-0003-3820-0115)
- Eleonora Vandini (ORCID: https://orcid.org/0000-0001-7581-4437)
- Michele Zoli (ORCID: https://orcid.org/0000-0002-9258-1775)
- Daniela Giuliani (ORCID: https://orcid.org/0000-0001-6061-5662)
- Martina Bodria
- Stefano Pioli (ORCID: https://orcid.org/0000-0001-7452-5991)
- Monica Piemontese
Institutions
- Università di Camerino (IT)
- University of Modena and Reggio Emilia (IT)
Publication Details
- Journal
- Brain Sciences
- Published
- 2026-10-05
- DOI
- https://doi.org/10.3390/brainsci16101069
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00