Successful Multidisciplinary Management of Acute‐On‐Chronic Liver Failure in a Twin Pregnancy Using Artificial Liver Support: A Case Report

ABSTRACT Introduction Acute‐on‐chronic liver failure (ACLF) in pregnancy is a rare, life‐threatening condition with high maternal and fetal mortality. Methods We report a twin‐pregnant patient with ACLF managed by a multidisciplinary team. Interventions included comprehensive medical therapy, seven sessions of artificial liver support (plasma exchange), symptom control, nutritional and psychological care, and prophylactic measures against mother‐to‐child transmission. Results The patient successfully delivered healthy twins. Postdelivery, both infants tested negative for HBsAg and HBV‐DNA, confirming effective prevention of vertical transmission. Maternal condition stabilized with treatment. Conclusion Multidisciplinary management incorporating artificial liver therapy and tailored obstetric care can achieve favorable maternal and neonatal outcomes in ACLF during twin pregnancy.