Oleogel-Based Formulations for Cosmetics and Pharmaceutical Applications: Current Landscape and Future Directions

Oleogels have attracted considerable interest as structured lipid systems due to their ability to immobilize liquid oils and tailor the physicochemical properties of formulations. Although much of the fundamental knowledge on oleogel development derives from food-related research, the unique structural, rheological, and textural properties of these systems have increasingly supported their exploration also for cosmetic and pharmaceutical purposes. This review aims to explore the relevance of oleogels in these industries by compiling and critically evaluating the current knowledge on cosmetic and pharmaceutical formulations, with particular emphasis on their composition, preparation methods, and the rationale underlying their selection and use. Studies on oleogels for cosmetic uses are limited, while in pharmaceuticals, oleogels have been extensively studied for topical drug delivery, being their use in oral, transdermal, and intraocular delivery less explored. Oleogels are versatile and biocompatible delivery systems, ideal for transporting lipophilic active ingredients. Their inner structure modulates drug delivery, making them promising vehicles for innovative cosmetic and pharmaceutical applications.