Contextual Homeostatic Continuity Framework (CHCF) Elevated: The Immune System as Topological Regulators in the UROA-STCT-RQIG Manifold

The classical ”Self-Nonself” paradigm of immunology fundamentally fails to explain microbiome symbiosis, fetal tolerance, autoimmunity, and tumor evasion. We introduce the Contextual Homeostatic Continuity Framework (CHCF), vastly elevated through Universal Rough Operator Algebra (UROA), the Seonggil Theory of Complex Torsion (STCT), and Rough Quantum Information Geometry (RQIG). The immune system is radically redefined: it does not actively distinguish biological origin (self/foreign), but strictly acts as a macroscopic topological operator that smooths non-commutative tissue roughness, untangles acute temporal discontinuities, and navigates context-dependent information geodesics to rigorously maintain systemic homeostasis.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-10-05
DOI
https://doi.org/10.5281/zenodo.23157586
Primary Topic
Artificial Immune Systems Applications
Type
preprint
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preprint

Contextual Homeostatic Continuity Framework (CHCF) Elevated: The Immune System as Topological Regulators in the UROA-STCT-RQIG Manifold

Seonggil Lee
Zenodo (CERN European Organization for Nuclear Research)
Artificial Immune Systems Applications
preprint

Contextual Homeostatic Continuity Framework (CHCF) Elevated: The Immune System as Topological Regulators in the UROA-STCT-RQIG Manifold

Seonggil Lee
preprint en

Abstract

The classical ”Self-Nonself” paradigm of immunology fundamentally fails to explain microbiome symbiosis, fetal tolerance, autoimmunity, and tumor evasion. We introduce the Contextual Homeostatic Continuity Framework (CHCF), vastly elevated through Universal Rough Operator Algebra (UROA), the Seonggil Theory of Complex Torsion (STCT), and Rough Quantum Information Geometry (RQIG). The immune system is radically redefined: it does not actively distinguish biological origin (self/foreign), but strictly acts as a macroscopic topological operator that smooths non-commutative tissue roughness, untangles acute temporal discontinuities, and navigates context-dependent information geodesics to rigorously maintain systemic homeostasis.

Zenodo (CERN European Organization for Nuclear Research)
Artificial Immune Systems Applications
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