Natural Phenolic Compounds in Pain Management and Regenerative Medicine: From Molecular Mechanisms to Therapeutic Applications

Natural phenolic compounds are plant-derived compounds known for their potent antioxidant and anti-inflammatory properties. In addition, natural phenolic compounds are being investigated for their potential applications in pain management, and tissue engineering and regenerative medicine. This review aims to emphasize the anti-inflammatory and anti-oxidant effects of natural phenolic compounds and to highlight their important roles in pain management and tissue engineering and regenerative medicine. In pain management, natural phenolic compounds demonstrated promising results in suppressing orofacial, pelvic, neuropathic, and musculoskeletal pain compared to conventional pain management drugs or by synergistically acting with those drugs. While in tissue engineering and regenerative medicine, natural phenolic compounds were found to enhance the differentiation potential of stem cells into different lineages by increasing the expression of differentiation markers and were also found to enhance proliferation and migration of different types of dental stem cells. In conclusion, natural phenolic compounds, due to their unique properties, are promising in protocols of pain management as well as in tissue engineering and regenerative medicine.