Reframing antimicrobial resistance as a land-system challenge through environmental pathways and climate interactions
Abstract Antimicrobial resistance (AMR) is a planetary health challenge, yet land-system change remains overlooked. This review examines how agriculture, urbanisation, waste management, deforestation, aquaculture and climate-driven transitions shape resistance through altered input intensity, habitat reorganisation and enhanced connectivity. It identifies evidence gaps across vulnerable settings and proposes pathway-based surveillance, integrated datasets, longitudinal studies and coordinated interventions to reduce resistance selection, persistence and transmission across connected landscapes, informing research, policy and implementation.
Authors
- Fiona L. Henriquez (ORCID: https://orcid.org/0000-0002-5534-1019)
- John E. Pearl (ORCID: https://orcid.org/0000-0001-7496-6367)
- Holly J. Tipper (ORCID: https://orcid.org/0000-0002-1857-9204)
- William H. Gaze (ORCID: https://orcid.org/0000-0002-9345-6204)
- Susheel Bhanu Busi (ORCID: https://orcid.org/0000-0001-7559-3400)
- Abel Bulamu Ekiri (ORCID: https://orcid.org/0000-0001-9758-808X)
- Jennifer Cole (ORCID: https://orcid.org/0000-0001-8787-8892)
- Laura Carter (ORCID: https://orcid.org/0000-0002-1146-7920)
- Emma Lamb (ORCID: https://orcid.org/0000-0001-8447-7153)
- Katy Davis (ORCID: https://orcid.org/0000-0001-6936-4222)
- Nuno Silva
- Rosie Steege
Publication Details
- Journal
- npj Antimicrobials and Resistance
- Published
- 2026-10-05
- DOI
- https://doi.org/10.1038/s44259-026-00282-9
- Primary Topic
- Pharmaceutical and Antibiotic Environmental Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00