Precision biomarkers of the exercise-induced immune "open window": a scoping review of the validation readiness of conventional and omics candidates

Scoping review protocol (JBI methodology; PRISMA-ScR), version 3.1 (amendments PRE-004 to PRE-006), with its operational appendices (search strategy, screening, extraction, appraisal and synthesis specifications), JSON templates, generated Excel workbooks and build scripts. This scoping review will map human evidence on candidate immune biomarkers measured within the exercise-induced "open window", used here solely as an organizing construct that defines the post-exercise period after an identifiable bout, the sampling time points and the marker families to be charted. Across conventional immune indices and omics candidates in generally healthy adults after single identifiable bouts (Core A) and across repeated bouts in the same individuals (Support B), we will chart, marker by marker, which of seven precision-evidence domains have actually been investigated: analytical reliability, temporal validity, immune specificity, individualization, functional or clinical linkage, independent validation and use, and feasibility. The resulting per-marker validation-readiness map is a descriptive domain-by-domain profile, not a score, ranking or development ladder. The review does not test whether an open window of increased infection susceptibility exists, and original authors' endorsement or rejection of that hypothesis neither determines eligibility nor weights evidence. Version 3.1 records the amendments adopted after the screening and charting pilots (PRE-004 charting rules, PRE-005 two-stage screening, PRE-006 database set PubMed/Web of Science/Scopus plus a Google Scholar supplement, search-stage limits and search strategy v0.9) and is archived after the formal database searches of 5 October 2026 and before screening. No eligibility decisions or review results are included; raw database exports are not part of the archive.