Chromosomal Abnormalities, Drug Sensitivity and Resistance in Hematological Malignancies: A Comprehensive Overview by the Francophone Group of Hematological Cytogenetics ( GFCH )
Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a comprehensive review of chromosomal abnormalities associated with drug sensitivity and resistance in hematological disorders. This work highlights the emergence of alteration-driven therapy, with certain agents (e.g., tyrosine kinase inhibitors, menin inhibitors, venetoclax) used across entities sharing common molecular lesions, while others remain disease-specific, such as in Helicobacter pylori-associated lymphomas.
Authors
- Lucienne Michaux (ORCID: https://orcid.org/0000-0002-8357-7942)
- Audrey Bidet (ORCID: https://orcid.org/0000-0003-0992-8377)
- Nathalie Douet‐Guilbert (ORCID: https://orcid.org/0000-0003-2197-5213)
- Nada Assaf (ORCID: https://orcid.org/0000-0002-3352-2660)
- Élise Chapiro (ORCID: https://orcid.org/0000-0003-3427-7596)
- Florence Nguyen‐Khac (ORCID: https://orcid.org/0000-0003-3107-6668)
- Jasmine Chauzeix (ORCID: https://orcid.org/0000-0002-8283-6295)
- Inge Govaerts (ORCID: https://orcid.org/0000-0003-0166-5293)
- Hélène Guermouche (ORCID: https://orcid.org/0000-0003-4074-1623)
- Pauline Roynard (ORCID: https://orcid.org/0009-0009-9549-304X)
- Marie‐Bérengère Troadec (ORCID: https://orcid.org/0000-0003-2668-9670)
- Nathalie Auger (ORCID: https://orcid.org/0000-0002-9744-4470)
- Lauren Véronèse (ORCID: https://orcid.org/0000-0002-4414-7974)
- Christine Lefebvre (ORCID: https://orcid.org/0000-0003-0424-3731)
- Hippolyte Guérineau (ORCID: https://orcid.org/0009-0008-4190-3704)
- Hend Chaker Masmoudi (ORCID: https://orcid.org/0000-0002-4258-7028)
- Jean‐Baptiste Gaillard (ORCID: https://orcid.org/0000-0002-6102-014X)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- University of Monastir (TN)
- Université Paris Cité (FR)
- Universitair Ziekenhuis Leuven (BE)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Institut Gustave Roussy (FR)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Université (FR)
- Centre de Recherche des Cordeliers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- American University of Beirut Medical Center (LB)
- Institut de Génétique Moléculaire de Montpellier (FR)
- Centre Hospitalier Universitaire de Limoges (FR)
- Pitié-Salpêtrière Hospital (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Groupe Hospitalier de l'Institut Catholique de Lille (FR)
- Institut Pasteur de Tunis (TN)
- Thea (France) (FR)
- Centre Hospitalier de Versailles (FR)
- Génétique, Génomique Fonctionnelle et Biotechnologies (FR)
- Université de Limoges (FR)
- American University of Beirut (LB)
Publication Details
- Journal
- American Journal of Hematology
- Published
- 2026-10-04
- DOI
- https://doi.org/10.1002/ajh.70499
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00