Novel Substituted Pyrazoles as SARM1 Inhibitors

Abstract This patent discloses a series of pyrazole derivatives as novel sterile alpha and TIR motif containing 1 (SARM1) inhibitors for the potential treatment of SARM1-related diseases, including neurodegenerative disorders. It provides details on the pyrazoles, their preparations, pharmaceutical compositions, and therapeutic applications.

Authors

Steven H. Liang (ORCID: https://orcid.org/0000-0003-1413-6315)
Jian Rong (ORCID: https://orcid.org/0000-0002-3960-1669)

Institutions

Emory University (US)

Publication Details

Journal: ACS Medicinal Chemistry Letters
Published: 2026-10-04
DOI: https://doi.org/10.1021/acsmedchemlett.6c00498
Primary Topic: Synthesis and biological activity
Type: article
Field-Weighted Citation Impact: 0.00

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article

Novel Substituted Pyrazoles as SARM1 Inhibitors

Steven H. Liang, Jian Rong

Oct 4, 2026

ACS Medicinal Chemistry Letters

Synthesis and biological activity

article

Novel Substituted Pyrazoles as SARM1 Inhibitors

Steven H. Liang, Jian Rong

October 4, 2026article en

Abstract

ACS Medicinal Chemistry Letters

Emory University (US)

Good health and well-being

Openalex Percentile: Top 24%

Synthesis and biological activity

DOI Open Access PDF OpenAlex

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Novel Substituted Pyrazoles as SARM1 Inhibitors — Steven H. Liang, Jian Rong · ACS Medicinal Chemistry Letters (2026) | TGRS Research Map | TGRS