Mechanochemical Synthesis and Functionalization of Oxadiazo[2.2.2]octenes Through Oxidative Nitroso Diels–Alder Reaction and Hetero‐Cope Rearrangement
ABSTRACT The present work reports a straightforward approach for the mechanochemical oxidative nitroso Diels–Alder (DA) reaction for the rapid synthesis of oxadiazo[2.2.2]octenes and a mechanochemical [3+3] hetero‐Cope rearrangement to access the corresponding dioxazines within reduced reaction time (up to 1.5 min and 1.5 h, respectively), high yields and reproducibility toward different functional groups.
Authors
- Fabio Bellina (ORCID: https://orcid.org/0000-0002-4939-7008)
- Antonio Del Vecchio (ORCID: https://orcid.org/0000-0001-9759-4420)
- Mauro Pineschi (ORCID: https://orcid.org/0000-0001-6063-2198)
- Marco Lessi (ORCID: https://orcid.org/0000-0002-0090-7070)
- Caterina Campinoti (ORCID: https://orcid.org/0009-0007-8566-711X)
- Simona Marchetti
Institutions
- University of Pisa (IT)
- Consorzio Interuniversitario Reattività Chimica e Catalisi (IT)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2026-09-30
- DOI
- https://doi.org/10.1002/ajoc.70557
- Primary Topic
- Crystallography and molecular interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00