Occupational chronic myeloid leukaemia in a radiology technician: a quantitative Probability of Causation assessment.

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative neoplasm associated with the Philadelphia chromosome, and ionizing radiation is a well-established leukemogenic factor. Despite regulated dose limits, occupationally related CML remains rare and under-recognized. We present the case of a 53-year-old male radiology technician diagnosed with CML following the detection of leukocytosis during routine periodic fitness-for-work surveillance. The patient had 29 years of documented occupational exposure with a cumulative effective dose of 150 mSv, without acute incidents. While International Commission on Radiological Protection recommendations primarily focus on fitness-for-work rather than malignancy screening, this case-the first officially recognized and institutionally attributed occupational CML in our country-demonstrates how systematic surveillance can facilitate the identification of serious haematological conditions in high-exposure (Class A) workers. It provides a structured Probability of Causation assessment to support occupational attribution and statutory recognition within a regulated low-dose environment on a probabilistic basis.

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Publication Details

Journal
PubMed
Published
2026-09-30
DOI
https://doi.org/10.1093/rpd/ncag116
Primary Topic
Radiation Dose and Imaging
Type
article
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article

Occupational chronic myeloid leukaemia in a radiology technician: a quantitative Probability of Causation assessment.

Elif Sedanur UTLU, Elif Reyhan Şahin, Aysu Timuroğlu
PubMed
Radiation Dose and Imaging
article

Occupational chronic myeloid leukaemia in a radiology technician: a quantitative Probability of Causation assessment.

Elif Sedanur UTLU, Elif Reyhan Şahin, Aysu Timuroğlu
article en

Abstract

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative neoplasm associated with the Philadelphia chromosome, and ionizing radiation is a well-established leukemogenic factor. Despite regulated dose limits, occupationally related CML remains rare and under-recognized. We present the case of a 53-year-old male radiology technician diagnosed with CML following the detection of leukocytosis during routine periodic fitness-for-work surveillance. The patient had 29 years of documented occupational exposure with a cumulative effective dose of 150 mSv, without acute incidents. While International Commission on Radiological Protection recommendations primarily focus on fitness-for-work rather than malignancy screening, this case-the first officially recognized and institutionally attributed occupational CML in our country-demonstrates how systematic surveillance can facilitate the identification of serious haematological conditions in high-exposure (Class A) workers. It provides a structured Probability of Causation assessment to support occupational attribution and statutory recognition within a regulated low-dose environment on a probabilistic basis.

PubMed
Erzurum Regional Training and Research Hospital (TR)
Openalex Percentile: Top 12%
Radiation Dose and Imaging
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