Bibliometric Analysis of Platelet-Rich Plasma Applications in Thin Endometrium and Recurrent Implantation Failure: Research Trends, Thematic Clusters, and Collaborative Patterns (2000–2025)

Abstract Background: Thin endometrium and recurrent implantation failure (RIF) are among the most refractory challenges in assisted reproductive technology. Autologous platelet-rich plasma (PRP) has emerged as a promising regenerative intervention; however, the global structure of this rapidly expanding research field has not been systematically mapped. Aims and Objectives: The aim of this study was to characterize the bibliometric landscape of PRP research in thin endometrium and RIF; identify the most productive countries, journals, and authors; delineate thematic clusters; and trace temporal research trends over the period 2000–2025. Materials and Methods: A Title-field search of Web of Science (WoS; n = 473) and Scopus ( n = 86, after excluding 3 errata/unrelated records) was conducted in June 2025. After DOI-based deduplication removed 62 overlapping records, 24 Scopus-unique documents were added to the WoS dataset, yielding 497 documents. Bradford’s Law, Lotka’s Law, keyword co-occurrence networks, and country coauthorship networks were computed with Python 3.10. Results: Of 497 documents, 93% were published from 2015 onward, with 91 publications recorded by the June 2025 search date. Original articles (62.0%) and reviews (23.3%) dominated. Human Reproduction ( n = 29) and Fertility and Sterility ( n = 28) were the most productive journals; Bradford’s Law identified a four-journal core. China led the country output ( n = 112), followed by the USA (56), India (50), and Iran (45). Seven thematic clusters were identified. Among the WoS-indexed records, the total citations were 8498 and the h-index was 50. Conclusion: PRP research in thin endometrium and RIF has expanded exponentially since 2015 but remains geographically concentrated and dominated by small single-center studies. Multicenter randomized controlled trials with standardized protocols and live birth as the primary endpoint are urgently needed.

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Journal
The Journal of Medical Research
Published
2026-09-30
DOI
https://doi.org/10.4103/jmr.jmr_43_26
Primary Topic
Reproductive System and Pregnancy
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article
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Bibliometric Analysis of Platelet-Rich Plasma Applications in Thin Endometrium and Recurrent Implantation Failure: Research Trends, Thematic Clusters, and Collaborative Patterns (2000–2025)

Süreyya Sarıdaş Demir, Bülent Demir
The Journal of Medical Research
Reproductive System and Pregnancy
article

Bibliometric Analysis of Platelet-Rich Plasma Applications in Thin Endometrium and Recurrent Implantation Failure: Research Trends, Thematic Clusters, and Collaborative Patterns (2000–2025)

Süreyya Sarıdaş Demir, Bülent Demir
article en

Abstract

Abstract Background: Thin endometrium and recurrent implantation failure (RIF) are among the most refractory challenges in assisted reproductive technology. Autologous platelet-rich plasma (PRP) has emerged as a promising regenerative intervention; however, the global structure of this rapidly expanding research field has not been systematically mapped. Aims and Objectives: The aim of this study was to characterize the bibliometric landscape of PRP research in thin endometrium and RIF; identify the most productive countries, journals, and authors; delineate thematic clusters; and trace temporal research trends over the period 2000–2025. Materials and Methods: A Title-field search of Web of Science (WoS; n = 473) and Scopus ( n = 86, after excluding 3 errata/unrelated records) was conducted in June 2025. After DOI-based deduplication removed 62 overlapping records, 24 Scopus-unique documents were added to the WoS dataset, yielding 497 documents. Bradford’s Law, Lotka’s Law, keyword co-occurrence networks, and country coauthorship networks were computed with Python 3.10. Results: Of 497 documents, 93% were published from 2015 onward, with 91 publications recorded by the June 2025 search date. Original articles (62.0%) and reviews (23.3%) dominated. Human Reproduction ( n = 29) and Fertility and Sterility ( n = 28) were the most productive journals; Bradford’s Law identified a four-journal core. China led the country output ( n = 112), followed by the USA (56), India (50), and Iran (45). Seven thematic clusters were identified. Among the WoS-indexed records, the total citations were 8498 and the h-index was 50. Conclusion: PRP research in thin endometrium and RIF has expanded exponentially since 2015 but remains geographically concentrated and dominated by small single-center studies. Multicenter randomized controlled trials with standardized protocols and live birth as the primary endpoint are urgently needed.

The Journal of Medical Research
Çanakkale Onsekiz Mart Üniversitesi (TR), Canakkale Onsekiz Mart Universitesi Tip Fakultesi Hastanesi (TR)
Openalex Percentile: Top 19%
Reproductive System and Pregnancy
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