Bibliometric Analysis of Platelet-Rich Plasma Applications in Thin Endometrium and Recurrent Implantation Failure: Research Trends, Thematic Clusters, and Collaborative Patterns (2000–2025)
Abstract Background: Thin endometrium and recurrent implantation failure (RIF) are among the most refractory challenges in assisted reproductive technology. Autologous platelet-rich plasma (PRP) has emerged as a promising regenerative intervention; however, the global structure of this rapidly expanding research field has not been systematically mapped. Aims and Objectives: The aim of this study was to characterize the bibliometric landscape of PRP research in thin endometrium and RIF; identify the most productive countries, journals, and authors; delineate thematic clusters; and trace temporal research trends over the period 2000–2025. Materials and Methods: A Title-field search of Web of Science (WoS; n = 473) and Scopus ( n = 86, after excluding 3 errata/unrelated records) was conducted in June 2025. After DOI-based deduplication removed 62 overlapping records, 24 Scopus-unique documents were added to the WoS dataset, yielding 497 documents. Bradford’s Law, Lotka’s Law, keyword co-occurrence networks, and country coauthorship networks were computed with Python 3.10. Results: Of 497 documents, 93% were published from 2015 onward, with 91 publications recorded by the June 2025 search date. Original articles (62.0%) and reviews (23.3%) dominated. Human Reproduction ( n = 29) and Fertility and Sterility ( n = 28) were the most productive journals; Bradford’s Law identified a four-journal core. China led the country output ( n = 112), followed by the USA (56), India (50), and Iran (45). Seven thematic clusters were identified. Among the WoS-indexed records, the total citations were 8498 and the h-index was 50. Conclusion: PRP research in thin endometrium and RIF has expanded exponentially since 2015 but remains geographically concentrated and dominated by small single-center studies. Multicenter randomized controlled trials with standardized protocols and live birth as the primary endpoint are urgently needed.
Authors
- Süreyya Sarıdaş Demir (ORCID: https://orcid.org/0000-0002-4051-3703)
- Bülent Demir (ORCID: https://orcid.org/0000-0001-6608-9886)
Institutions
- Çanakkale Onsekiz Mart Üniversitesi (TR)
- Canakkale Onsekiz Mart Universitesi Tip Fakultesi Hastanesi (TR)
Publication Details
- Journal
- The Journal of Medical Research
- Published
- 2026-09-30
- DOI
- https://doi.org/10.4103/jmr.jmr_43_26
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00