Synthesis, Biological Properties, and Docking Study of 5-Substituted 2-[2-(Aryl)vinyl]-6-methylpyrimidin-4(3H)-ones
Abstract 5-Substituted 6-methyl-2-[(E)-2-aryl)ethenyl]pyrimidin-4(3H)-ones and 2,4-dioxo-6-[(E)-2-arylethenyl]-1,2,3,4-tetrahydropyrimidine-5-carbaldehydes were obtained by condensation of 5-substituted 2,6-dimethylpyrimidin-4(3H)-ones and 6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde with aromatic aldehydes, respectively. The antibacterial and antifungal properties of the obtained compounds were studied and a docking study was carried out against four targets.
Authors
- Anna Sukiasyan (ORCID: https://orcid.org/0009-0003-9716-2777)
- Astghik A. Shahkhatuni (ORCID: https://orcid.org/0000-0003-1848-5256)
- Artur A. Hambardzumyan (ORCID: https://orcid.org/0000-0001-9526-7768)
- Z. A. Hovasyan (ORCID: https://orcid.org/0000-0001-6698-7184)
- M. Yu. Danghyan (ORCID: https://orcid.org/0000-0001-7703-1591)
- А. А. Harutyunyan (ORCID: https://orcid.org/0000-0003-0641-5453)
- Jemma L. Barseghyan (ORCID: https://orcid.org/0009-0005-6179-0266)
- Hasmik A. Sargsyan (ORCID: https://orcid.org/0009-0004-7447-7781)
Institutions
- Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry (AM)
- H.Buniatian Institute of Biochemistry (AM)
- Eurasia International University (AM)
- Scientific Technological Center of Organic and Pharmaceutical Chemistry (AM)
- National Academy of Sciences of Armenia (AM)
Publication Details
- Journal
- Russian Journal of General Chemistry
- Published
- 2026-09-30
- DOI
- https://doi.org/10.1134/s107036322660219x
- Primary Topic
- Multicomponent Synthesis of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 0.00