Escitalopram-induced Hyponatremia in a 70-year-old Male: A Case Report

Selective serotonin reuptake inhibitors (SSRIs) are among the most widely prescribed antidepressants for various psychiatric conditions, such as major depressive disorder (MDD) and generalized anxiety disorder (GAD).They are associated with the well-documented side effect of hyponatremia, particularly in elderly and debilitated patients.SSRIs carry a threefold increased risk of hyponatremia when compared with other antidepressants.Escitalopram, a newer SSRI, is now widely used due to its high efficacy, minimal drug interactions, and favorable tolerability profile.However, it has been associated with hyponatremia, a relatively rare and poorly documented adverse effect of this seemingly benign drug.We present the case of a 70-year-old male who developed recurrent episodes of hyponatremia with altered sensorium while taking escitalopram, which resolved after discontinuing the drug.This case highlights the importance for clinicians to remain aware of this potentially severe adverse effect in a drug often regarded as low-risk.