Electrochemical Divergent Transformation of Flavonoids to Dihydroflavonols and 3-Iodoflavones
Abstract We report an electrochemically regulated divergent C–H functionalization of flavonoids that enables the controllable synthesis of dihydroflavonols or 3-iodoflavones from the same substrates by simply switching the electrolyte and solvent. This protocol operates in an undivided cell at room temperature under air, featuring tunable selectivity, no need for external oxidants or transition-metal catalysts, and operational simplicity. Mechanistic studies identify the key reaction intermediates.
Authors
- Xinyue Li (ORCID: https://orcid.org/0009-0007-4068-3423)
- Z Y Zhang (ORCID: https://orcid.org/0009-0000-4832-642X)
- Jiawei Guo (ORCID: https://orcid.org/0000-0001-5921-0932)
- Sun Yi (ORCID: https://orcid.org/0000-0003-4056-7848)
- Changsheng Qin (ORCID: https://orcid.org/0009-0005-7618-9326)
- Fanghua Ji (ORCID: https://orcid.org/0000-0002-2101-3930)
- J. Wang (ORCID: https://orcid.org/0009-0001-1759-3020)
- Guangbin Jiang (ORCID: https://orcid.org/0000-0002-8840-4741)
- Shoucai Wang (ORCID: https://orcid.org/0000-0002-9738-8309)
- Jierong Liu
- Chenxu Li
- Lanyu Yang
Institutions
- Guilin University of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-09-30
- DOI
- https://doi.org/10.1021/acs.orglett.6c03424
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00