Potential Benefit of Ruxolitinib in Suspected Ocular and Neurological Transplant‐Associated Thrombotic Microangiopathy After Allogeneic Stem Cell Transplantation: A Case Report and Review
ABSTRACT We describe a rare case of suspected delayed‐onset TA‐TMA with ocular and neurological involvement following allo‐HSCT. The condition was refractory to standard therapies; neurological improvement was temporally associated with ruxolitinib initiation, suggesting a possible GVHD overlap. This report supports a multidisciplinary approach to complex post‐transplant endothelial injury and supports further investigation of JAK inhibition in selected cases.
Authors
- Sophie Porcheron (ORCID: https://orcid.org/0000-0002-1630-6421)
- Bertrand Bourre (ORCID: https://orcid.org/0000-0002-2459-2480)
- Antoine Bonnevalle
- G. Sauvetre
- Fabrice Jardin (ORCID: https://orcid.org/0000-0002-6804-7943)
- Vincent Camus (ORCID: https://orcid.org/0000-0002-6845-221X)
- Paul Goupillou (ORCID: https://orcid.org/0000-0001-9665-3521)
- Dominique Penther (ORCID: https://orcid.org/0000-0003-1775-344X)
- Antoine Arandilla
- Mustafa Alani
- Maximilien Grall
- Lise‐Marie Pillet
- Adrien Lefevre
- Sydney Dubois
Institutions
- Hôpital Charles-Nicolle (FR)
- Hôpital Lariboisière (FR)
- Centre Hospitalier Universitaire de Rouen (FR)
- Centre Henri Becquerel
Publication Details
- Journal
- Clinical Case Reports
- Published
- 2026-09-29
- DOI
- https://doi.org/10.1002/ccr3.73660
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00