Preventing infections after CD19‐directed chimeric antigen receptor T‐cell therapies for lymphoma: a consensus practice statement
Abstract Chimeric antigen receptor (CAR) T‐cell therapies directed against c luster of differentiation 19 ( CD19) are a standard of care for relapsed or refractory B‐cell lymphomas. Infection is the leading cause of non‐relapse mortality, and this risk may persist for years after CAR T‐cell receipt. Recipients of CAR T‐cells can present in various clinical settings, and few trials have prospectively assessed prevention and management of infection in this group. This position statement provides Australian and New Zealand clinicians with a rational approach to preventing, investigating and managing infections after CD19‐directed CAR T‐cell therapy for lymphoma.
Authors
- Robert Weinkove (ORCID: https://orcid.org/0000-0003-3645-7988)
- Adam G. Stewart (ORCID: https://orcid.org/0000-0002-7262-7529)
- Monica A. Slavin (ORCID: https://orcid.org/0000-0002-8443-314X)
- Emily Blyth (ORCID: https://orcid.org/0000-0002-7849-7139)
- Andrea S. Henden (ORCID: https://orcid.org/0000-0003-2261-169X)
- P J George (ORCID: https://orcid.org/0000-0003-0184-2528)
- Benjamin W. Teh (ORCID: https://orcid.org/0000-0003-0213-5470)
- Gemma K. Reynolds (ORCID: https://orcid.org/0000-0002-9561-3592)
- Lynette Chui Yen Chee (ORCID: https://orcid.org/0000-0002-4250-4448)
- Olivia Bupha‐Intr
- Chan Yoon Cheah (ORCID: https://orcid.org/0000-0001-7988-1565)
- Hang Quach (ORCID: https://orcid.org/0000-0002-4796-3352)
- Michael John Dickinson (ORCID: https://orcid.org/0000-0002-1492-5966)
- Nicole O'Leary (ORCID: https://orcid.org/0009-0000-4338-2246)
- Aine Hurley (ORCID: https://orcid.org/0009-0009-4157-9817)
- Zoe McQuilten
Institutions
- The University of Sydney (AU)
- The Royal Melbourne Hospital (AU)
- University of Auckland (NZ)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- The University of Western Australia (AU)
- Malaghan Institute of Medical Research (NZ)
- Royal Brisbane and Women's Hospital (AU)
- Austin Hospital (AU)
- Peter MacCallum Cancer Centre (AU)
- Wellington Hospital (NZ)
- Sir Charles Gairdner Hospital (AU)
- Westmead Hospital (AU)
- St Vincent's Hospital Melbourne (AU)
- Westmead Institute for Medical Research (AU)
- Austin Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Internal Medicine Journal
- Published
- 2026-09-30
- DOI
- https://doi.org/10.1111/imj.70644
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00