BK Virus-Associated Hemorrhagic Cystitis in Nontransplanted Children With Hematological Malignancies: A Single-Center Case Series
Background: BK virus–associated hemorrhagic cystitis (BKV-HC) is well recognized after hematopoietic stem-cell transplantation but remains poorly described in nontransplanted children with hematological malignancies. Observations: We retrospectively identified 6 children with leukemia or lymphoma who developed BKV-HC over a 17-year period. Dysuria and macroscopic hematuria were the most common manifestations. One patient developed urinary obstruction and acute kidney injury. Median symptom duration was 16 days. Most patients received supportive care, and all but one recovered completely without sequelae. Conclusions: BKV-HC is an uncommon complication in nontransplanted children receiving chemotherapy for hematological malignancies. Clinical outcomes are generally favorable with conservative management.
Authors
- Georgina Morón‐Cazalilla (ORCID: https://orcid.org/0000-0001-6592-5205)
- Susana Rives (ORCID: https://orcid.org/0000-0002-5658-1831)
- Julià Götzens (ORCID: https://orcid.org/0000-0002-4139-5323)
- José Luís Dapena (ORCID: https://orcid.org/0000-0002-6711-7479)
- Anna Alonso‐Saladrigues (ORCID: https://orcid.org/0000-0002-3195-5470)
- Antoni Noguera‐Julián (ORCID: https://orcid.org/0000-0001-7485-0583)
- Nazaret Sánchez‐Sierra (ORCID: https://orcid.org/0000-0003-1640-8425)
- Silvia Simó Nebot (ORCID: https://orcid.org/0000-0003-2115-1695)
- Marina Pons‐Espinal (ORCID: https://orcid.org/0000-0002-4249-2045)
- Cristina Esteva
- Laura Arqués (ORCID: https://orcid.org/0009-0004-3356-4846)
- Ana Valls-Lafon
Institutions
- Hospital Sant Joan de Déu Barcelona (ES)
- Instituto de Salud Carlos III (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Leukemia Research Foundation (US)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Leukemia and Lymphoma Society (US)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Journal of Pediatric Hematology/Oncology
- Published
- 2026-09-30
- DOI
- https://doi.org/10.1097/mph.0000000000003288
- Primary Topic
- Polyomavirus and related diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00