Bilateral Ectopia Lentis and Aortic Regurgitation: A Case of Marfan Syndrome with Multisystem Manifestations

Abstract Marfan syndrome (MFS) is a systemic connective tissue disorder with significant ocular and cardiovascular involvement. This report describes the case of a 45-year-old male presenting with progressive bilateral vision loss over 5 years, more severe in the right eye. Examination showed no light perception in the right eye, diminished vision in the left, bilateral ectopia lentis, corneal stromal degeneration, and right eye retinal detachment. Systemic features included tall stature, arachnodactyly, aortic regurgitation, and left ventricular systolic dysfunction, confirmed by echocardiography. A clinical diagnosis of MFS was established. Due to poor prognosis in the right eye, cataract extraction with scleral-fixated intraocular lens implantation was performed on the left eye under peribulbar anesthesia. Postoperative recovery was uneventful with improved vision (6/18). This case highlights the need for a multidisciplinary collaboration for optimal management of MFS.