Maternal vaccination against COVID-19, influenza, pertussis, and respiratory syncytial virus: a scoping review

Abstract Pregnancy and early infancy are periods of heightened vulnerability, with SARS-CoV-2 and influenza infections potentially linked to adverse pregnancy outcomes, including preterm birth and stillbirth. Maternal vaccination provides direct protection to mothers by active immunisation and to infants by passive immunisation. This scoping review mapped and described published literature on maternal vaccination against COVID-19, influenza, pertussis, and respiratory syncytial virus (RSV). It includes information on the outcome domains studied and if timing of vaccination was examined, with the aim of identifying evidence gaps and supporting decision-makers in choosing priority areas for subsequent systematic review topics. A comprehensive literature search across multiple databases of studies published from January 2000 to October 2025 identified 635 publications (540 publications of primary studies, 95 evidence syntheses). Studies on COVID-19 (260 publications of studies, 45 reviews), influenza (161 publications of studies, 29 reviews), pertussis (113 publications of studies, 20 reviews), and RSV (20 publications of studies, 11 reviews) were analysed. Available evidence on COVID-19, influenza, and pertussis vaccination on efficacy, effectiveness, safety and immunogenicity outcomes is considerable. RSV vaccination evidence is limited. Updated systematic reviews would be helpful to clarify the optimal timing of COVID-19 and influenza vaccination and the effectiveness and safety of the coadministration of influenza and pertussis vaccines.

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Publication Details

Journal
npj Vaccines
Published
2026-09-29
DOI
https://doi.org/10.1038/s41541-026-01545-2
Primary Topic
COVID-19 Impact on Reproduction
Type
article
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article

Maternal vaccination against COVID-19, influenza, pertussis, and respiratory syncytial virus: a scoping review

KM Saif‐Ur‐Rahman, Marlena C. Kaczmarek, Gerald Gartlehner, Laura Sánchez-Cambronero et al.
npj Vaccines
COVID-19 Impact on Reproduction
article

Maternal vaccination against COVID-19, influenza, pertussis, and respiratory syncytial virus: a scoping review

KM Saif‐Ur‐Rahman, Marlena C. Kaczmarek, Gerald Gartlehner, Laura Sánchez-Cambronero, Goranka Petrović, Kate Olsson, Johanna Rubin, Anna J. M. Aabakke, Andreea Iulia Dobrescu, Christina Chittilappilly, Lisa Affengruber, Marianne Röbl-Mathieu, Arianna Gadinger, Jean‐Daniel Lelièvre, Declan Devane, Mirjana Lana Kosanović Ličina, Larisa Pinte, Susanne Strömdahl, Ana Fernández Dueñas, Isolde Sommer, Irma Klerings, Kirsten Maertens, Gernot Wagner, Simona Maria Ruță, Daniel Floret, Camilla Neubauer-Bruckner, Petek Eylul Taneri, Anne-Claude Cremieux
article en

Abstract

Abstract Pregnancy and early infancy are periods of heightened vulnerability, with SARS-CoV-2 and influenza infections potentially linked to adverse pregnancy outcomes, including preterm birth and stillbirth. Maternal vaccination provides direct protection to mothers by active immunisation and to infants by passive immunisation. This scoping review mapped and described published literature on maternal vaccination against COVID-19, influenza, pertussis, and respiratory syncytial virus (RSV). It includes information on the outcome domains studied and if timing of vaccination was examined, with the aim of identifying evidence gaps and supporting decision-makers in choosing priority areas for subsequent systematic review topics. A comprehensive literature search across multiple databases of studies published from January 2000 to October 2025 identified 635 publications (540 publications of primary studies, 95 evidence syntheses). Studies on COVID-19 (260 publications of studies, 45 reviews), influenza (161 publications of studies, 29 reviews), pertussis (113 publications of studies, 20 reviews), and RSV (20 publications of studies, 11 reviews) were analysed. Available evidence on COVID-19, influenza, and pertussis vaccination on efficacy, effectiveness, safety and immunogenicity outcomes is considerable. RSV vaccination evidence is limited. Updated systematic reviews would be helpful to clarify the optimal timing of COVID-19 and influenza vaccination and the effectiveness and safety of the coadministration of influenza and pertussis vaccines.

npj Vaccines
Université Claude Bernard Lyon 1 (FR), University of Copenhagen (DK), Public Health Agency of Sweden (SE), Universität für Weiterbildung Krems (AT), University of Antwerp (BE), Carol Davila University of Medicine and Pharmacy (RO), RTI International (US), Ollscoil na Gaillimhe – University of Galway (IE), Robert Koch Institute (DE), Copenhagen University Hospital (DK), Centre Hospitalier Universitaire Henri-Mondor (FR), Düsseldorf University Hospital (DE), Hrvatski zavod za javno zdravstvo (HR), Hôpitaux Universitaires Henri-Mondor (FR), Andrija Stampar Teaching Institute of Public Health (HR), Trials Methodology Research Network (IE), Heinrich Heine University Düsseldorf (DE), European Centre for Disease Prevention and Control (SE)
Good health and well-being
Openalex Percentile: Top 8%
COVID-19 Impact on Reproduction
DOIOpen Access PDFOpenAlex
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