Intrinsic timescale develops hierarchically from sensorimotor to association cortex in youth and stabilizes in adulthood
Intrinsic timescale is a commonly used measure of spontaneous neural dynamics that quantifies the temporal window of processing of neuronal populations. Intrinsic timescale displays a hierarchical cortical organization across multiple species and imaging modalities, with shorter timescales in sensorimotor cortex compared to association cortex. However, less is known about how intrinsic timescale evolves during human brain development and whether its cortical maturation patterns generalize to independent developmental samples. Here we estimate the intrinsic timescale in two independent cross-sectional datasets of youth (HCPD: n = 565; HBN: n = 729; age range 8–22 years) and investigate its neurodevelopmental patterns. We find that developmental patterns in the intrinsic timescale follow a hierarchical pattern that recapitulates an axis spanning sensorimotor to association cortices (S–A axis). Our analysis of an independent healthy young adult dataset (HCPYA: n = 973, age range 22–37 years) underscores the specificity of these developmental findings, suggesting that the intrinsic timescale develops along the S–A axis in youth and stabilizes in adulthood. Together, these results reveal convergence between major axes of cortical organization and development, highlighting intrinsic timescale as a principled marker of hierarchical brain maturation in youth.
Authors
- Leah H. Somerville (ORCID: https://orcid.org/0000-0002-3747-6884)
- Alexandre R. Franco (ORCID: https://orcid.org/0000-0002-1552-1090)
- Deanna M. Barch (ORCID: https://orcid.org/0000-0003-1693-8506)
- Audrey C. Luo (ORCID: https://orcid.org/0000-0001-6798-1876)
- Tien T. Tong (ORCID: https://orcid.org/0000-0002-1940-3198)
- Joëlle Bagautdinova (ORCID: https://orcid.org/0000-0001-7201-467X)
- Russell Taki Shinohara (ORCID: https://orcid.org/0000-0001-8627-8203)
- Theodore Daniel Satterthwaite (ORCID: https://orcid.org/0000-0001-7072-9399)
- Golia Shafiei (ORCID: https://orcid.org/0000-0002-2036-5571)
- Michael Peter Milham (ORCID: https://orcid.org/0000-0003-3532-1210)
- Gregory Kiar (ORCID: https://orcid.org/0000-0001-8915-496X)
- Matthew Cieslak (ORCID: https://orcid.org/0000-0002-1931-4734)
- Valerie J. Sydnor (ORCID: https://orcid.org/0000-0002-8640-668X)
- Linden Parkes (ORCID: https://orcid.org/0000-0002-9329-7207)
- Elizabeth A. Flook (ORCID: https://orcid.org/0000-0002-0192-0496)
- Dani S. Bassett (ORCID: https://orcid.org/0000-0002-6183-4493)
- Taylor Salo (ORCID: https://orcid.org/0000-0001-9813-3167)
- Yong Fan
Institutions
- Rutgers, The State University of New Jersey (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Children's Hospital of Philadelphia (US)
- Harvard University (US)
- University of Pittsburgh (US)
- Washington University in St. Louis (US)
- Child Mind Institute (US)
- New York University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- PLoS Biology
- Published
- 2026-09-29
- DOI
- https://doi.org/10.1371/journal.pbio.3004037
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00