Temporal Divergence of True and False Alarms in Pediatric Nocturnal Seizure Monitoring

Seizure detection devices can improve the safety of children with epilepsy, yet high false alarms limit their clinical applicability. Here, we investigated whether specific time periods are disproportionately prone to false alarms. We analyzed 2876 NightWatch alarms occurring between 19:00 and 09:00 in 65 children (ages 3-16, 48% female). Temporal distributions differed significantly between true and false alarms (p < 0.001), with a significant divergence in skewness (p = 0.001); notably, 30% of false alarms occurred between 06:00 and 09:00. This suggests NightWatch performance is adversely affected by wakefulness and morning arousal. Our findings support exploring time- or state-dependent detection thresholds to reduce false alarms. Trial Registration: The PROMISE (NCT03909984) and LICSENSE (NTR4115/NR395) trials were registered at the Dutch Trial Registry.

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Publication Details

Journal
Annals of Clinical and Translational Neurology
Published
2026-09-29
DOI
https://doi.org/10.1002/acn3.70530
Primary Topic
Healthcare Technology and Patient Monitoring
Type
article
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article

Temporal Divergence of True and False Alarms in Pediatric Nocturnal Seizure Monitoring

Mohammad Shahbakhti, Roland D. Thijs, Frans S. S. Leijten, Anemoon T. Bosch et al.
Annals of Clinical and Translational Neurology
Healthcare Technology and Patient Monitoring
article

Temporal Divergence of True and False Alarms in Pediatric Nocturnal Seizure Monitoring

Mohammad Shahbakhti, Roland D. Thijs, Frans S. S. Leijten, Anemoon T. Bosch, R.H.C. Lazeron, Job A.M. van der Palen, Johannes van Dijk
article en

Abstract

Seizure detection devices can improve the safety of children with epilepsy, yet high false alarms limit their clinical applicability. Here, we investigated whether specific time periods are disproportionately prone to false alarms. We analyzed 2876 NightWatch alarms occurring between 19:00 and 09:00 in 65 children (ages 3-16, 48% female). Temporal distributions differed significantly between true and false alarms (p < 0.001), with a significant divergence in skewness (p = 0.001); notably, 30% of false alarms occurred between 06:00 and 09:00. This suggests NightWatch performance is adversely affected by wakefulness and morning arousal. Our findings support exploring time- or state-dependent detection thresholds to reduce false alarms. Trial Registration: The PROMISE (NCT03909984) and LICSENSE (NTR4115/NR395) trials were registered at the Dutch Trial Registry.

Annals of Clinical and Translational Neurology
Leiden University (NL), Universität Ulm (DE), Leiden University Medical Center (NL), Medisch Spectrum Twente (NL), University Medical Center Utrecht (NL), Kempenhaeghe (NL), Stichting Epilepsie Instellingen Nederland (NL), UCL Queen Square Institute of Neurology (GB), University College London (GB), Eindhoven University of Technology (NL), University of Twente (NL)
Openalex Percentile: Top 9%
Healthcare Technology and Patient Monitoring
DOIOpen Access PDFOpenAlex
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Temporal Divergence of True and False Alarms in Pediatric Nocturnal Seizure Monitoring — Mohammad Shahbakhti, Roland D. Thijs, et al. · Annals of Clinical and Translational Neurology (2026) | TGRS Research Map | TGRS