A Comprehensive Review of Strategies to Enhance Quality and Safety in Infertility Laboratories.

Assisted reproductive technology (ART) laboratories are complex environments in which human gametes and embryos are handled through highly sensitive procedures. Because of procedural complexity, manual documentation, high workload and the need for precise identification at ev-ery step, these laboratories are inherently vulnerable to er-rors that may compromise patient safety, clinical outcomes and confidence in ART. Potential hazards may arise from equipment malfunction, human error, environmental insta-bility or deviation from validated procedures. Therefore, a comprehensive framework for risk assessment, risk man-agement and safety monitoring is essential. This review dis-cusses the main risk factors in ART laboratories and exam-ines established mitigation strategies, including witnessing systems, process mapping, key performance indicators and quality management systems. It also summarizes recom-mended procedures and case-based evidence for improving laboratory safety and performance. Current evidence indi-cates that proactive risk assessment, electronic witnessing, emerging artificial intelligence tools and strict adherence to international guidelines can reduce the likelihood of errors and support high-quality, safe patient care.