Rh(III)-Catalyzed Direct C7 Alkylation of Indolines with Nitroalkenes
Abstract The Rh(III)-catalyzed C7-alkylation of indolines with nitroalkenes under an ambient atmosphere is disclosed, affording diverse 7-(2-nitroalkyl)indolines with excellent chemo- and regioselectivity. The directing group is readily removable, and the resulting products can be oxidized to deliver 7-(2-nitroalkyl)indoles. Moreover, a plausible mechanism is proposed on the basis of control experiments.
Authors
- Shuang‐Liang Liu (ORCID: https://orcid.org/0000-0001-8596-3989)
- Haoran Yang (ORCID: https://orcid.org/0000-0001-7579-0738)
- Liming Zhou
- Kaixin Cheng
- Jiejie Wang
- Lin Liu
Institutions
- Zhengzhou University of Light Industry (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-09-29
- DOI
- https://doi.org/10.1021/acs.joc.6c01873
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00