Design and Simulation of Multilayer SPR Biosensor Based on BK7/Ag/BN/BlueP/WSe 2 /BP for Label‐Free Detection of A549 Lung Cancer Cells

ABSTRACT A label‐free surface plasmon resonance (SPR) biosensor was explored for the detection of A549 lung cancer cells. The proposed sensing platform uses a multi‐layer platform consisting of a BK7 prism, Ag, BN, BlueP/WSe 2 heterostructure, and BP layers. To excite the surface plasmons, a silver coating was applied to the BK7 prism using the Kretschmann arrangement. These BN, BlueP/WSe 2 , and BP layers increase the confinement of the electromagnetic field and light–matter interaction and reduce the dissipation of plasmonic energy. The transfer matrix method (TMM), which uses angular interrogation at an operating wavelength of 633 nm, was used for the numerical analysis. The optimized multilayer architecture exhibited excellent sensing capability, with a sensitivity of 366.589°/RIU, quality factor of 100.054 RIU − 1 , detection accuracy of 1.8010 deg − 1 , and full width at half maximum (FWHM) of 3.6639°. The results show the efficiency of the proposed design for A549 lung cancer detection.