CHRONIC RHINOSINUSITIS (CRS): CURRENT CONCEPTS IN ETIOLOGY AND PATHOPHYSIOLOGY WITH NOVEL THERAPEUTIC APPROACHES

Chronic rhinosinusitis (CRS) is an inflammatory disease of the paranasal sinuses, which commonly results in chronic sinonasal symptoms. In the United States, 1% to 5% of the population has chronic rhinosinusitis. CRS is defined as 2 or more of 4 cardinal signs and symptoms (i.e., facial pain/pressure, hyposmia/anosmia, nasal discharge [anterior and/or posterior], nasal obstruction) irrespective of previous history of acute rhinosinusitis for a duration exceeding 12 consecutive weeks.[1]