Survival and disease reactivation after autologous stem cell transplantation for systemic sclerosis: a single-centre cohort

Systemic sclerosis (SSc) carries the highest disease-specific mortality among systemic rheumatic diseases; autologous haematopoietic stem cell transplantation (AHSCT) has emerged as 1 of the disease-modifying treatments for severe, rapidly progressive disease [1–3]. However, real-world data on predictors and patterns of disease reactivation after AHSCT remain limited, and consensus relapse criteria have only recently been proposed [4]. We aimed to characterise the incidence, timing, and clinical features of disease reactivation following AHSCT in SSc.

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Journal
EULAR Rheumatology Open
Published
2026-09-30
DOI
https://doi.org/10.1016/j.ero.2026.100241
Primary Topic
Systemic Sclerosis and Related Diseases
Type
article
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article

Survival and disease reactivation after autologous stem cell transplantation for systemic sclerosis: a single-centre cohort

Andy Abril, Claire Wilson, Ernesto Ayala, Madiha Iqbal et al.
EULAR Rheumatology Open
Systemic Sclerosis and Related Diseases
article

Survival and disease reactivation after autologous stem cell transplantation for systemic sclerosis: a single-centre cohort

Andy Abril, Claire Wilson, Ernesto Ayala, Madiha Iqbal, Rachel F Sauls
article en

Abstract

Systemic sclerosis (SSc) carries the highest disease-specific mortality among systemic rheumatic diseases; autologous haematopoietic stem cell transplantation (AHSCT) has emerged as 1 of the disease-modifying treatments for severe, rapidly progressive disease [1–3]. However, real-world data on predictors and patterns of disease reactivation after AHSCT remain limited, and consensus relapse criteria have only recently been proposed [4]. We aimed to characterise the incidence, timing, and clinical features of disease reactivation following AHSCT in SSc.

EULAR Rheumatology OpenVol. 2(4)
Mayo Clinic (US), Jacksonville College (US), Mayo Clinic in Florida (US)
Openalex Percentile: Top 13%
Systemic Sclerosis and Related Diseases
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Survival and disease reactivation after autologous stem cell transplantation for systemic sclerosis: a single-centre cohort — Andy Abril, Claire Wilson, et al. · EULAR Rheumatology Open (2026) | TGRS Research Map | TGRS