Migraine in Real-World Clinical Practice: Patient Burden, Healthcare Utilization and Unmet Needs—A Cross-Sectional Analysis of the I-GRAINE Study
What are the main findings?Migraine care in Italy is characterized by a mismatch between healthcare resource utilization and clinical needs, with limited primary-care involvement, repeated specialist consultations, and healthcare nomadism.Healthcare resource utilization is substantial, including extensive diagnostic testing—predominantly brain imaging—as well as emergency department visits, detoxification cycles, and repeated access to headache centers.
Authors
- Massimo Filippi (ORCID: https://orcid.org/0000-0002-5485-0479)
- Cinzia Aurilia (ORCID: https://orcid.org/0000-0002-2658-2243)
- Maria Albanese (ORCID: https://orcid.org/0000-0002-5113-2017)
- Annalisa Gai
- Piero Barbanti (ORCID: https://orcid.org/0000-0002-5670-3755)
- Prabha Cristina Ranchicchio
- Sabina Cevoli (ORCID: https://orcid.org/0000-0003-4668-4295)
- Pietro Antonio Bruno
- Francesca Pistoia (ORCID: https://orcid.org/0000-0003-0790-4240)
- Fabrizio Di Stani
- Mattia Sansone (ORCID: https://orcid.org/0000-0002-1232-2651)
- Massimo Autunno (ORCID: https://orcid.org/0000-0002-7526-2799)
- Francesco Bono (ORCID: https://orcid.org/0000-0002-4650-6635)
- Stefano Bonassi (ORCID: https://orcid.org/0000-0003-3833-6717)
- Ilaria Cetta
- Valentina Favoni (ORCID: https://orcid.org/0000-0001-5335-2438)
- Gennaro Saporito (ORCID: https://orcid.org/0009-0001-2390-0533)
- Jesuély Spieckert de Souza (ORCID: https://orcid.org/0000-0002-9319-5710)
- Maurizio Zucco
- Giovanna Viticchi (ORCID: https://orcid.org/0000-0002-1799-1563)
- Licia Grazzi (ORCID: https://orcid.org/0000-0001-6535-1109)
- Paolo Solla (ORCID: https://orcid.org/0000-0002-2982-0665)
- Francesco Tazza (ORCID: https://orcid.org/0000-0002-3515-3475)
- Roberto De Simone (ORCID: https://orcid.org/0000-0002-0954-8668)
- Paola Torelli (ORCID: https://orcid.org/0000-0002-4072-2353)
- Carlo Tomino (ORCID: https://orcid.org/0000-0003-1823-2195)
- Tommaso Ercoli (ORCID: https://orcid.org/0000-0002-3260-1754)
- Alfonsina Di Summa
- Simone Braca (ORCID: https://orcid.org/0000-0002-9733-8344)
- Francesca Cortese (ORCID: https://orcid.org/0000-0001-9791-1537)
- Barbara Petolicchio (ORCID: https://orcid.org/0000-0003-2775-928X)
- Frederico Friedrich (ORCID: https://orcid.org/0000-0001-6939-0340)
- Alfonso Coppola
- Cecilia Camarda
- Vanise Grassi (ORCID: https://orcid.org/0000-0002-9859-9167)
- Annamaria Porreca (ORCID: https://orcid.org/0000-0003-3278-1561)
- Gabriella Egeo (ORCID: https://orcid.org/0000-0003-3068-4522)
- Carlo Colosimo (ORCID: https://orcid.org/0000-0002-2216-3973)
- Cinzia Finocchi (ORCID: https://orcid.org/0000-0003-4385-1203)
- Marco Russo (ORCID: https://orcid.org/0000-0001-5171-8555)
- Carla Zanferrari (ORCID: https://orcid.org/0000-0002-6001-1698)
- Ludovica Ferraù
- Steno Rinalduzzi
- Rosario Grugno (ORCID: https://orcid.org/0009-0000-9700-2157)
- Domenico Cosenza
- Alberto Doretti (ORCID: https://orcid.org/0000-0002-1015-7365)
- Francesca Gragnani
- Stefano Caproni (ORCID: https://orcid.org/0000-0002-8627-9879)
- Simone Quintana (ORCID: https://orcid.org/0000-0001-8160-0339)
- Giulia Fiorentini
- Marco Bartolini (ORCID: https://orcid.org/0000-0003-2518-6369)
- Fabrizio Vernieri (ORCID: https://orcid.org/0000-0002-9594-9336)
- Fabio Valguarnera
- Elisabetta Iannaccone
- Rossana Terlizzi
- Laura Di Clemente (ORCID: https://orcid.org/0009-0001-7849-9484)
- Stefano Messina (ORCID: https://orcid.org/0000-0002-1928-2787)
- Riccardo Altavilla (ORCID: https://orcid.org/0000-0002-7637-9980)
- Monica Laura Bandettini di Poggio
- Paola Scatena
- Renata Rao
- Florindo d’Onofrio (ORCID: https://orcid.org/0009-0007-1647-3389)
- Antonio Carnevale
- Sara Cazzulo
- Martina Guarinoni
- Alessandra Cherchi
- Italian Migraine Registry (I-GRAINE) Study Group
Institutions
- University of Messina (IT)
- University of Rome Tor Vergata (IT)
- Marche Polytechnic University (IT)
- University of Parma (IT)
- Universidade Federal de Ciências da Saúde de Porto Alegre (BR)
- Vita-Salute San Raffaele University (IT)
- Università Campus Bio-Medico (IT)
- University of Sassari (IT)
- University of Cagliari (IT)
- University of L'Aquila (IT)
- Santa Maria Nuova Hospital (IT)
- Santa Casa Hospital (BR)
- Martin University (US)
- San Raffaele University of Rome (IT)
- Magna Graecia University (IT)
- Ospedale San Paolo (IT)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Ospedale di Bolzano (IT)
- Azienda Ospedaliera San Camillo-Forlanini (IT)
- Ellis Hospital (US)
- Ospedale San Filippo Neri (IT)
- Ospedale San Carlo (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Azienda Ospedaliero Universitaria di Sassari (IT)
- Azienda Sanitaria Locale di Asti (IT)
- Azienda Ospedaliera S.Giuseppe Moscati (IT)
- Ospedale “M. Bufalini” di Cesena (IT)
- Federico II University Hospital (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- IRCCS Ospedale San Raffaele (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Ospedale Sandro Pertini (IT)
- Ospedale di Parma (IT)
- Hospital São Lucas da PUCRS (BR)
- Azienda Ospedaliera Universitaria Policlinico "G. Martino" (IT)
- Campus Bio Medico University Hospital (IT)
- Ospedale Generale Regionale Francesco Miulli (IT)
- Ospedale Policlinico San Martino (IT)
- Centro Neurolesi Bonino Pulejo (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- University of Naples Federico II (IT)
- University of Brescia (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Brain Sciences
- Published
- 2026-09-29
- DOI
- https://doi.org/10.3390/brainsci16101040
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00