Bypassing the Translational Bottleneck in Cancer Nanomedicine: A Unified Bedside Framework

This correspondence outlines a novel, closed-loop bedside framework for advanced cancer drug delivery. By unifying machine learning-driven shape customization with point-of-care erythrocyte membrane coatings and pH-sensitive molecular linkages, the proposed framework integrates biological, physical, and computational barriers into a singular clinical architecture to successfully overcome patient-specific delivery bottlenecks and immune clearance.