Grouped asymptomatic papulonodular lesions over the thigh

A male in his early 20s presented with asymptomatic swellings in the right thigh for 4-5 years.e lesions were non-tender and non-progressive.e patient's past and family histories were non-contributory.On clinical examination, multiple skin colored to hyperpigmented, soft to firm, and painless papules and nodules were distributed on the medial aspect of the right thigh in a segmental pattern [Figure 1a].e lesion showed "button-holing" on digital invagination.e regional lymph nodes were not palpable.ere were no hyperpigmented macules, no soft papules on the face, flexural freckling, bone tenderness or ocular/oral lesions.Dermatoscopy (Dermlite DL4, 3 Gen, CA, USA, Polarized X10) revealed brown pigmentary lines, a peripheral halo of brown pigmentation, and a fingerprint-like pattern [Figure 1b].Ultrasonography revealed hypoechoic masses, and histopathology from a skin-colored papule (Hematoxylin & Eosin) showed a circumscribed, unencapsulated spindle cell tumor composed of haphazardly arranged spindle cells with elongated, plump nuclei, fine chromatin, inconspicuous nucleoli, and moderate eosinophilia to partial vacuolation in a collagenous stroma [Figure 2a-b].e underlying adnexal gland and dermis were unremarkable.No nuclear atypia was seen.Further special staining and immunohistochemistry (IHC) revealed S100 positivity [Figure 2c] and clusture of differentiation (CD) 34 positivity [Figure 2d].Slit lamp examination was reported to be normal.

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Publication Details

Journal
Cosmoderma
Published
2026-09-28
DOI
https://doi.org/10.25259/csdm_161_2026
Primary Topic
Cancer and Skin Lesions
Type
article
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article

Grouped asymptomatic papulonodular lesions over the thigh

Saikat Mitra, Priyanka Kowe, Chethan Cheeranahalli Mutt, Shivangi Singh
Cosmoderma
Cancer and Skin Lesions
article

Grouped asymptomatic papulonodular lesions over the thigh

Saikat Mitra, Priyanka Kowe, Chethan Cheeranahalli Mutt, Shivangi Singh
article en

Abstract

A male in his early 20s presented with asymptomatic swellings in the right thigh for 4-5 years.e lesions were non-tender and non-progressive.e patient's past and family histories were non-contributory.On clinical examination, multiple skin colored to hyperpigmented, soft to firm, and painless papules and nodules were distributed on the medial aspect of the right thigh in a segmental pattern [Figure 1a].e lesion showed "button-holing" on digital invagination.e regional lymph nodes were not palpable.ere were no hyperpigmented macules, no soft papules on the face, flexural freckling, bone tenderness or ocular/oral lesions.Dermatoscopy (Dermlite DL4, 3 Gen, CA, USA, Polarized X10) revealed brown pigmentary lines, a peripheral halo of brown pigmentation, and a fingerprint-like pattern [Figure 1b].Ultrasonography revealed hypoechoic masses, and histopathology from a skin-colored papule (Hematoxylin & Eosin) showed a circumscribed, unencapsulated spindle cell tumor composed of haphazardly arranged spindle cells with elongated, plump nuclei, fine chromatin, inconspicuous nucleoli, and moderate eosinophilia to partial vacuolation in a collagenous stroma [Figure 2a-b].e underlying adnexal gland and dermis were unremarkable.No nuclear atypia was seen.Further special staining and immunohistochemistry (IHC) revealed S100 positivity [Figure 2c] and clusture of differentiation (CD) 34 positivity [Figure 2d].Slit lamp examination was reported to be normal.

CosmodermaVol. 6
All India Institute of Medical Sciences, Nagpur (IN)
Openalex Percentile: Top 9%
Cancer and Skin Lesions
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Grouped asymptomatic papulonodular lesions over the thigh — Saikat Mitra, Priyanka Kowe, et al. · Cosmoderma (2026) | TGRS Research Map | TGRS