PLATINUM -METHIONINE COMPLEX AS AN EMERGING CYANIDE COUNTERMEASURE: CHEMISTRY, MECHANISM, AND PRECLINICAL EVIDENCE FROM A SWIN PILOT STUDY

ABSTRACT Toxicity from cyanide is quick and often dangerous due to its ability to interfere with the cellular production of energy. Although there are established antidotes for cyanide toxicity, there are still some challenges that allow for the development of alternate therapies. The strong binding of cyanide to platinum made these compounds promising cyanide scavenger's. Of these, the platinum- methionine complex (Met2pt) has shown the most promise in preliminary studies. This review looks at cyanide toxicity, currently available antidotes, and the development of platinum-based cyanide scavengers. The formation of complex cyanide ligands and the platinum-methionine complex is covered. Preclinical studies of the platinum-methionine complex are covered, with an emphasis on a recent swine study. This study provides preliminary evidence for the efficacy of Met2pt. Finally, this review looks at the limitations of the complex and focuses on the safety and pharmacokinetics of platinum-methionine, as well as its clinical applicability. Overall, preclinical studies have been encouraging, and platinum-methionine is a good area of research for an anti-cyanide drug; however, more preclinical research is needed before it can consider a safe and effective drug for use in humans. Keywords: Cyanide toxicity; Platinum-methionine complex; Met2pt ; Cyanide scavenging; Platinum(II) complexes; Swine model