Global Research Trends and Mechanistic Insights into Natural Products for Dyslipidemia: A Bibliometric Analysis (2000–2025)

Hyperlipidemia is a major metabolic disorder that leads to cardiovascular diseases. Natural products have drawn more attention as supplemental treatment approaches for lipid management. However, there is still a lack of adequate characterizations of the worldwide research scene and new developments. The objective of this study was to assess emerging research, collaborative networks, and worldwide research trends concerning natural products for hyperlipidemia. This study conducted a bibliometric analysis of publications indexed in Scopus and the Web of Science core collection (WoS) between 2000 and 2025. VOSviewer and Bibliometrix/biblioshiny were applied to performance the analysis on science mapping analyses and thematic evolution. An evidence matrix was developed to integrate mechanistic insights; 4243 entries were found in Scopus and 2328 in WoS dataset, indicating a consistent publication trend across databases. China was the biggest contributor, followed by the US, India, and Iran. Beijing University of Chinese Medicine and Mashhad University of Medical Sciences were prominent establishments. Three main research clusters were found based on keyword co-occurrence analysis: mechanistic studies concentrating on inflammation and molecular signaling pathways, experimental animal models examining lipid metabolism, and clinical studies on dyslipidemia. Overall, our bibliometric study reveals important scientific trends that could direct future translational and precision medicine research on hyperlipidemia.