Outside Back Cover: Decoding Atypical G‐Quadruplexes and Their Interactome in Liquid Biopsies via Integrated Electroanalytical–Proteomic Technologies
In the Research Article e3768019, Víctor Ruiz-Valdepeñas Montiel, Rodrigo Barderas, Susana Campuzano, and co-workers report a versatile electroanalytical platform for the global profiling of G-quadruplexes (G4s) in cancer biopsies. By integrating magnetic immunocapture with advanced proteomics, the platform enables selective isolation of endogenous G4-forming DNA regions, reveals stage-dependent remodelling of the plasma G4 interactome, and identifies a prognostic G4-binding protein. Image by Víctor Ruiz-Valdepeñas Montiel.
Authors
- Víctor Ruiz‐Valdepeñas Montiel (ORCID: https://orcid.org/0000-0002-8865-1531)
- Rodrigo Barderas (ORCID: https://orcid.org/0000-0003-3539-7469)
- Susana Campuzano (ORCID: https://orcid.org/0000-0002-9928-6613)
- Ana Montero‐Calle (ORCID: https://orcid.org/0000-0001-5141-0454)
- María Garranzo‐Asensio (ORCID: https://orcid.org/0000-0003-0850-4986)
- Javier Velázquez-Gutiérrez (ORCID: https://orcid.org/0000-0002-5995-2677)
- Andrea Cabrero-Martín (ORCID: https://orcid.org/0009-0001-0785-1495)
- José M. Pingarrón
- A. Julio Reviejo
Institutions
- Universidad Complutense de Madrid (ES)
- Instituto de Salud Carlos III (ES)
- Unidad Funcional de Investigación de Enfermedades Crónicas (ES)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2026-09-28
- DOI
- https://doi.org/10.1002/anie.2026-m2509040600
- Primary Topic
- DNA and Nucleic Acid Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00