THEORY OF OBJECTS. ARTICLE 17. 15 META COMPARTMENT: REPRODUCTIVE SECRETIONS (SEMEN, VAGINAL SECRETIONS). REPRODUCTIVE SECRETIONS AS A HORMONAL-METABOLIC MIRROR: PP/IT PROFILE AND RESTORATION OF METABOLIC DIVERSITY IN PEOPLE 55+

Reproductive secretions – semen and vaginal secretions – are a complex biological environment containing hormones, polyamines, prostaglandins, steroids, antimicrobial peptides, cytokines, and microbiota products critical to reproductive function and overall health. After the age of 55, the metabolomic diversity of reproductive secretions decreases dramatically: the number of detected metabolites drops from ~1300 to a critical threshold of less than 30, which is associated with atrophic vaginitis, vulvovaginal atrophy, erectile dysfunction, benign prostatic hyperplasia, prostatitis, hormonal disorders, and systemic inflammation. However, standard clinical analyses do not assess the metabolomic diversity of reproductive secretions. The article shows how the theory of objects allows you to measure the metabolic depletion of reproductive secretions, what diseases are associated with it, and how foods with a high PP/IT profile, including biogenic nutrition, restore metabolomic diversity. The PP/IT profile is a format for representing two independent indices: the density of objects and the toxicity index (IT). The notation 175/3 means 175 beneficial molecular species and 3 harmful ones per 100 g of product — this is not a fraction, but two independent numbers side by side, like a blood pressure of 120/80. The profile is tied to the vector of product parameters: variety, origin, method of production, condition, freshness, and storage conditions. A monitoring protocol and practical recommendations for people 55+ are proposed.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-09-28
DOI
https://doi.org/10.5281/zenodo.23015027
Primary Topic
Metabolomics and Mass Spectrometry Studies
Type
preprint
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preprint

THEORY OF OBJECTS. ARTICLE 17. 15 META COMPARTMENT: REPRODUCTIVE SECRETIONS (SEMEN, VAGINAL SECRETIONS). REPRODUCTIVE SECRETIONS AS A HORMONAL-METABOLIC MIRROR: PP/IT PROFILE AND RESTORATION OF METABOLIC DIVERSITY IN PEOPLE 55+

Лагода
Zenodo (CERN European Organization for Nuclear Research)
Metabolomics and Mass Spectrometry Studies
preprint

THEORY OF OBJECTS. ARTICLE 17. 15 META COMPARTMENT: REPRODUCTIVE SECRETIONS (SEMEN, VAGINAL SECRETIONS). REPRODUCTIVE SECRETIONS AS A HORMONAL-METABOLIC MIRROR: PP/IT PROFILE AND RESTORATION OF METABOLIC DIVERSITY IN PEOPLE 55+

Лагода
preprint en

Abstract

Reproductive secretions – semen and vaginal secretions – are a complex biological environment containing hormones, polyamines, prostaglandins, steroids, antimicrobial peptides, cytokines, and microbiota products critical to reproductive function and overall health. After the age of 55, the metabolomic diversity of reproductive secretions decreases dramatically: the number of detected metabolites drops from ~1300 to a critical threshold of less than 30, which is associated with atrophic vaginitis, vulvovaginal atrophy, erectile dysfunction, benign prostatic hyperplasia, prostatitis, hormonal disorders, and systemic inflammation. However, standard clinical analyses do not assess the metabolomic diversity of reproductive secretions. The article shows how the theory of objects allows you to measure the metabolic depletion of reproductive secretions, what diseases are associated with it, and how foods with a high PP/IT profile, including biogenic nutrition, restore metabolomic diversity. The PP/IT profile is a format for representing two independent indices: the density of objects and the toxicity index (IT). The notation 175/3 means 175 beneficial molecular species and 3 harmful ones per 100 g of product — this is not a fraction, but two independent numbers side by side, like a blood pressure of 120/80. The profile is tied to the vector of product parameters: variety, origin, method of production, condition, freshness, and storage conditions. A monitoring protocol and practical recommendations for people 55+ are proposed.

Zenodo (CERN European Organization for Nuclear Research)
Metabolomics and Mass Spectrometry Studies
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