Lysyl oxidase ( LOX )‐mediated remodeling of the extracellular matrix
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross-link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders, and cancer.
Authors
- Fernando Rodríguez‐Pascual (ORCID: https://orcid.org/0000-0002-9765-9578)
- Raquel Jiménez-Sánchez
- Verónica Romero-Albillo (ORCID: https://orcid.org/0009-0006-6783-1468)
- Marta Navarro-Gutierrez (ORCID: https://orcid.org/0000-0002-4676-0035)
Institutions
- Consejo Superior de Investigaciones Científicas (ES)
- Centro de Biología Molecular Severo Ochoa (ES)
Publication Details
- Journal
- FEBS Letters
- Published
- 2026-09-28
- DOI
- https://doi.org/10.1002/1873-3468.70472
- Primary Topic
- Microbial metabolism and enzyme function
- Type
- article
- Field-Weighted Citation Impact
- 0.00