THEORY OF OBJECTS. ARTICLE 8. 6 META-COMPARTMENT: URINE SECONDARY. SECONDARY URINE AS AN INTEGRAL MARKER OF METABOLIC AGING: PP/IT PROFILE AND RESTORATION OF METABOLOMIC DIVERSITY IN PEOPLE 55+

Secondary urine is the final product of excretion, reflecting the metabolic diversity of the entire body. After the age of 55, the metabolomic diversity of urine decreases sharply: the number of detected metabolites drops from 2650–3100 to a critical threshold of less than 1000, which is associated with a threefold increase in all-cause mortality, chronic kidney disease, metabolic syndrome, cardiovascular and neurodegenerative diseases. However, standard urinalysis assesses only a narrow set of parameters and does not reflect metabolomic diversity. The article shows how the theory of subjectabols allows you to measure metabolic depletion of urine, what diseases are associated with it, and how foods with a high PCP/IT profile, including biogenic nutrition, restore metabolomic diversity. The PP/IT profile is a format for representing two independent indices: the density of objects (PP) and the toxicity index (IT). The notation 170/3 means 170 beneficial molecular species and 3 harmful ones per 100 g of product — this is not a fraction, but two independent numbers side by side, like a blood pressure of 120/80. The profile is tied to the vector of product parameters: variety, origin, method of production, condition, freshness, and storage conditions. A monitoring protocol and practical recommendations for people 55+ are proposed.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-09-28
DOI
https://doi.org/10.5281/zenodo.23011351
Primary Topic
Metabolomics and Mass Spectrometry Studies
Type
preprint
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THEORY OF OBJECTS. ARTICLE 8. 6 META-COMPARTMENT: URINE SECONDARY. SECONDARY URINE AS AN INTEGRAL MARKER OF METABOLIC AGING: PP/IT PROFILE AND RESTORATION OF METABOLOMIC DIVERSITY IN PEOPLE 55+

Лагода
Zenodo (CERN European Organization for Nuclear Research)
Metabolomics and Mass Spectrometry Studies
preprint

THEORY OF OBJECTS. ARTICLE 8. 6 META-COMPARTMENT: URINE SECONDARY. SECONDARY URINE AS AN INTEGRAL MARKER OF METABOLIC AGING: PP/IT PROFILE AND RESTORATION OF METABOLOMIC DIVERSITY IN PEOPLE 55+

Лагода
preprint en

Abstract

Secondary urine is the final product of excretion, reflecting the metabolic diversity of the entire body. After the age of 55, the metabolomic diversity of urine decreases sharply: the number of detected metabolites drops from 2650–3100 to a critical threshold of less than 1000, which is associated with a threefold increase in all-cause mortality, chronic kidney disease, metabolic syndrome, cardiovascular and neurodegenerative diseases. However, standard urinalysis assesses only a narrow set of parameters and does not reflect metabolomic diversity. The article shows how the theory of subjectabols allows you to measure metabolic depletion of urine, what diseases are associated with it, and how foods with a high PCP/IT profile, including biogenic nutrition, restore metabolomic diversity. The PP/IT profile is a format for representing two independent indices: the density of objects (PP) and the toxicity index (IT). The notation 170/3 means 170 beneficial molecular species and 3 harmful ones per 100 g of product — this is not a fraction, but two independent numbers side by side, like a blood pressure of 120/80. The profile is tied to the vector of product parameters: variety, origin, method of production, condition, freshness, and storage conditions. A monitoring protocol and practical recommendations for people 55+ are proposed.

Zenodo (CERN European Organization for Nuclear Research)
Metabolomics and Mass Spectrometry Studies
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THEORY OF OBJECTS. ARTICLE 8. 6 META-COMPARTMENT: URINE SECONDARY. SECONDARY URINE AS AN INTEGRAL MARKER OF METABOLIC AGING: PP/IT PROFILE AND RESTORATION OF METABOLOMIC DIVERSITY IN PEOPLE 55+ — Лагода · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS