Cosmetic Eye Colour Change Requires Procedure-Specific Evidence: A Commentary on Laser Iris Depigmentation and Keratopigmentation

This commentary examines the evidence framework required for meaningful safety comparisons between cosmetic keratopigmentation (KTP) and laser iris depigmentation (LID). Because these procedures act on different anatomical tissues and involve different biological mechanisms, clinically relevant outcomes and adverse-event reporting should be procedure-specific. The manuscript reviews published safety signals for both approaches, discusses the biological fate of endogenous versus exogenous pigment, and proposes a standardized reporting checklist for laser iris depigmentation. The Lumineyes method is described as an author-developed, response-guided LID protocol candidate. No claim of independently verified comparative superiority or safety is made. This is a preprint commentary and contains no original patient dataset. Background and clinical context:https://mylumineyes.com/laser-eye-color-change/ Research archive:https://mylumineyes.com/research/