ACE2 POLYMORPHISMS (RS6629110 AND RS2106806) AND SEVERITY OF COVID 19 DISEASE IN MOSUL POPULATION OF IRAQ

Background: The biggest challenge that humanity has faced since 2019 is the spread of the Covid 19 pandemic worldwide. The researchers focused more on the mechanism by which the spike (S) protein of the virus binding with the ACE2 receptor and then enters the host. Methodology: In the current study, 124 individuals of COVID-19 patients were classified into three groups, Mild (N=39), Moderate (=40), and Sever (N=45) cases. We used an amplification refractory mutation system (ARMS-PCR) for ACE2 (rs6629110 and rs2106806) genotyping. Results: As the results show, there is no significant difference in the genotype distributions of ACE2 (rs6629110 and rs2106806). However, in over dominant models of ACE2 (rs6629110) CT genotype we indicate a relative increase in the value of the added ratio in moderate cases with OR 1.2879 (95%) CI = (0.5235 to 3.1683), p < 0.5817 and with OR 1.4006 (95%) CI = (0.5813 to 3.3743), p < 0.4527 in severe cases. Also, the codominant model in ACE2 rs2106806 (AA) genotype was observed a relative increase in the value of the added ratio in moderate cases with OR 1.9286 (95%) CI = (0.7020 to 5.2984), p < 0.2028 and with OR 2.4545 (95%) CI = (0.8940 to 6.7388), p < 0.0814 in severe cases. Conclusions: This study has found that generally an association between over dominant models of ACE2 (rs6629110) CT and increased symptoms of illness, but not significantly. Also findings the association between codominant models of ACE2 (rs2106806) AA and increased symptoms of illness, but not significantly. However, to prove the theory, we need more future studies with a larger number of volunteers, preferably from different populations. .