ABO and Rh Hemolytic Disease of the Fetus and Newborn

Hemolytic disease of the fetus and newborn (HDFN) is a blood disorder in which red blood cells are destroyed faster, leading to anemia. Our study focused on immune-mediated HDFN. The study included 86 newborns with HDFN. Samples were provided to two clinics in Georgia. Coombs tests were performed to confirm the presence of HDFN. Monoclonal antibodies were used to determine ABO and Rh blood group antigens. The genetic analysis was performed using the SNP rs8176719. ABO-HDFN was the majority, followed by Rh-HDFN (χ2 = 6.44, p = 0.04). the majority newborns with ABO-HDFN have A(II), Rh+ blood group (χ2 =141.16, p