THEORY OF OBJECTS. ARTICLE 13. 11 META-COMPARTMENT: EXHALED AIR. EXHALED AIR AS A VOLATILE MIRROR OF METABOLISM: PP/IT PROFILE AND RESTORATION OF METABOLOMIC DIVERSITY IN PEOPLE 55+

Exhaled air is a volatile metabolic environment containing more than 1,100 volatile organic compounds (VOCs) that reflect oxidative stress, microbial metabolism, lung function, and systemic metabolic processes. After age 55, the diversity of VOCs in exhaled air decreases dramatically: the number of detectable metabolites drops from more than 1,100 to a critical threshold of less than 300, which is associated with chronic obstructive pulmonary disease (COPD), asthma, lung cancer, metabolic syndrome, diabetes, and neurodegenerative diseases. However, standard clinical analyses do not evaluate the volatile metabolome. The article shows how the theory of exhaled air allows you to measure the metabolic depletion of exhaled air, what diseases are associated with it, and how foods with a high PP/IT profile, including biogenic nutrition, restore metabolomic diversity. The PP/IT profile is a format for representing two independent indices: the density of objects (PP) and the toxicity index (IT). The notation 250/8 means 250 beneficial molecular species and 8 harmful ones per 100 g of product — this is not a fraction, but two independent numbers side by side, like a blood pressure of 120/80. The profile is tied to the vector of product parameters: variety, origin, method of production, condition, freshness, and storage conditions. A monitoring protocol and practical recommendations for people 55+ are proposed.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-09-28
DOI
https://doi.org/10.5281/zenodo.23012879
Primary Topic
Advanced Chemical Sensor Technologies
Type
preprint
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THEORY OF OBJECTS. ARTICLE 13. 11 META-COMPARTMENT: EXHALED AIR. EXHALED AIR AS A VOLATILE MIRROR OF METABOLISM: PP/IT PROFILE AND RESTORATION OF METABOLOMIC DIVERSITY IN PEOPLE 55+

Лагода
Zenodo (CERN European Organization for Nuclear Research)
Advanced Chemical Sensor Technologies
preprint

THEORY OF OBJECTS. ARTICLE 13. 11 META-COMPARTMENT: EXHALED AIR. EXHALED AIR AS A VOLATILE MIRROR OF METABOLISM: PP/IT PROFILE AND RESTORATION OF METABOLOMIC DIVERSITY IN PEOPLE 55+

Лагода
preprint en

Abstract

Exhaled air is a volatile metabolic environment containing more than 1,100 volatile organic compounds (VOCs) that reflect oxidative stress, microbial metabolism, lung function, and systemic metabolic processes. After age 55, the diversity of VOCs in exhaled air decreases dramatically: the number of detectable metabolites drops from more than 1,100 to a critical threshold of less than 300, which is associated with chronic obstructive pulmonary disease (COPD), asthma, lung cancer, metabolic syndrome, diabetes, and neurodegenerative diseases. However, standard clinical analyses do not evaluate the volatile metabolome. The article shows how the theory of exhaled air allows you to measure the metabolic depletion of exhaled air, what diseases are associated with it, and how foods with a high PP/IT profile, including biogenic nutrition, restore metabolomic diversity. The PP/IT profile is a format for representing two independent indices: the density of objects (PP) and the toxicity index (IT). The notation 250/8 means 250 beneficial molecular species and 8 harmful ones per 100 g of product — this is not a fraction, but two independent numbers side by side, like a blood pressure of 120/80. The profile is tied to the vector of product parameters: variety, origin, method of production, condition, freshness, and storage conditions. A monitoring protocol and practical recommendations for people 55+ are proposed.

Zenodo (CERN European Organization for Nuclear Research)
Life in Land
Advanced Chemical Sensor Technologies
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THEORY OF OBJECTS. ARTICLE 13. 11 META-COMPARTMENT: EXHALED AIR. EXHALED AIR AS A VOLATILE MIRROR OF METABOLISM: PP/IT PROFILE AND RESTORATION OF METABOLOMIC DIVERSITY IN PEOPLE 55+ — Лагода · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS