Tau‐PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head‐to‐head comparison of Flortaucipir and MK6240

Abstract INTRODUCTION We compared the association between mild behavioral impairment (MBI) and first‐ versus second‐generation tau‐positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD). METHODS We assessed 110 individuals with head‐to‐head [ 18 F]MK6240 and [ 18 F]Flortaucipir tau‐PET. Voxel‐wise and region‐of‐interest analyses investigated relationships between tau‐PET and MBI Checklist (MBI‐C) scores, which were also compared across tau‐PET positivity and PET‐Braak stages. RESULTS For both tracers, MBI severity was associated with tau‐PET signal in all Braak regions and increased across PET‐Braak stages. [ 18 F]MK6240 showed more extensive voxel‐wise associations with MBI‐C scores and additional correlations with affective symptoms in stratified analyses by diagnostic groups. Tau positivity was associated with a higher frequency of MBI. Individuals positive for [ 18 F]MK6240 but negative for [ 18 F]Flortaucipir exhibited greater MBI burden than individuals negative for both tracers. DISCUSSION MBI in early AD is associated with tau‐PET, with [ 18 F]MK6240 providing greater sensitivity to detect MBI‐related symptoms.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2026-09-28
DOI
https://doi.org/10.1002/alz.71861
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
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article

Tau‐PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head‐to‐head comparison of Flortaucipir and MK6240

Tharick Ali Pascoal, Zahinoor Ismail, Joseph Therriault, Guilherme Povala et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Tau‐PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head‐to‐head comparison of Flortaucipir and MK6240

Tharick Ali Pascoal, Zahinoor Ismail, Joseph Therriault, Guilherme Povala, Eduardo Rigon Zimmer, K. -M. Ng, Belén Pascual, Nesrine Rahmouni, Arthur C. Macedo, Tevy Chan, Bruna Bellaver, David N. Soleimani‐Meigooni, Suzanne Baker, Firoza Zubeida Lussier, Étienne Aumont, Isabella Harb Bizzi, Fortea Juan, VJ Lowe, Hwamee Oh, Lydia Trudel, Pamela C.L. Ferreira, Rayan Mroué, Andreia Rocha, Delphine Oliva-Lopez, Emma Ruppert, Marina Pereira Gonçalves, Pedro Rosa‐Neto, for the HEAD Study, Livia Amaral, Gleb Bezgin, Marina Scop Medeiros, Seyyed Ali Hosseini, Joseph Masdeu, Cécile Tissot
article en

Abstract

Abstract INTRODUCTION We compared the association between mild behavioral impairment (MBI) and first‐ versus second‐generation tau‐positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD). METHODS We assessed 110 individuals with head‐to‐head [ 18 F]MK6240 and [ 18 F]Flortaucipir tau‐PET. Voxel‐wise and region‐of‐interest analyses investigated relationships between tau‐PET and MBI Checklist (MBI‐C) scores, which were also compared across tau‐PET positivity and PET‐Braak stages. RESULTS For both tracers, MBI severity was associated with tau‐PET signal in all Braak regions and increased across PET‐Braak stages. [ 18 F]MK6240 showed more extensive voxel‐wise associations with MBI‐C scores and additional correlations with affective symptoms in stratified analyses by diagnostic groups. Tau positivity was associated with a higher frequency of MBI. Individuals positive for [ 18 F]MK6240 but negative for [ 18 F]Flortaucipir exhibited greater MBI burden than individuals negative for both tracers. DISCUSSION MBI in early AD is associated with tau‐PET, with [ 18 F]MK6240 providing greater sensitivity to detect MBI‐related symptoms.

Alzheimer s & DementiaVol. 22(10)
Montreal Neurological Institute and Hospital (CA), Houston Methodist (US), Universidade Federal do Rio Grande do Sul (BR), Mayo Clinic (US), Lawrence Berkeley National Laboratory (US), University of Calgary (CA), University of Pittsburgh (US), Brown University (US), Douglas Mental Health University Institute (CA), Hospital de Sant Pau (ES), Instituto do Cérebro (BR), Hospital Moinhos de Vento (BR), Biomedical Research Networking Center on Neurodegenerative Diseases (ES), Southwestern Medical Center (US), University Memory and Aging Center (US), Duke-NUS Medical School (SG), Faculdade São Leopoldo Mandic (BR), National Neuroscience Institute (SG), Weill Cornell Medicine (US), Institut de Recerca Sant Pau (ES), Centre intégré universitaire de santé et de services sociaux de l'Ouest-de-l’Île-de-Montréal (CA), Hotchkiss Brain Institute (CA), Research Institute of the McGill University Health Centre (CA), O'Brien Institute for Public Health (CA), Pontifícia Universidade Católica do Rio Grande do Sul (BR), McGill University (CA), The University of Texas Southwestern Medical Center (US)
Openalex Percentile: Top 11%
Dementia and Cognitive Impairment Research
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