Extract of Cissus sicyoides L. modulates metabolic biomarkers in an intergenerational obesity model

Abstract Objectives This study aimed to evaluate its metabolic effects of Cissus sicyoides L. aqueous extract treatment in Wistar rats subjected to an intergenerational obesity model. Methods Male offspring (F1 generation) of female rats with monosodium glutamate-induced obesity (F0 generation) were classified as non-obese and obese in adulthood based on the Lee index, and were treated with an aqueous extract of C. sicyoides (8.91 mg/kg) for 28 days. Phenolic compounds in the extract were identified by HPLC-DAD-ESI-MSn. Metabolic parameters, including body mass, food and water intake, biochemical markers, and renal function, were evaluated. Results Treatment with C. sicyoides extract reduced glycemia and non-HDL cholesterol levels in obese rats. Additionally, decreases in body mass, Lee index, and relative liver weight were observed. A total of 11 phenolic compounds were identified, including flavonoids and phenolic acids. Conclusions The extract of C. sicyoides in an intergenerational obesity rat model showed reductions in glycemia, non-HDL cholesterol, and body weight, as well as modulation of hepatic parameters, suggesting its use as an adjuvant strategy in metabolic disorders.