THEORY OF OBJECTS. ARTICLE 18. 16 META-COMPARTMENT: AMNIOTIC FLUID. AMNIOTIC FLUID AS A MEDIUM OF METABOLIC PROGRAMMING

Amniotic fluid is a complex biological environment that surrounds the fetus and provides it with nutrition, protection, movement, and metabolic programming. In the context of late pregnancy or analysis of the mechanisms of aging, the metabolomic diversity of amniotic fluid decreases dramatically: the number of detected metabolites drops from ~2351 to a critical threshold of less than 500, which is associated with intrauterine growth restriction, preterm birth, preeclampsia, gestational diabetes, and metabolic disorders in the offspring. However, standard clinical analyses do not assess the metabolomic diversity of amniotic fluid. The article shows how the theory of objects allows you to measure the metabolic depletion of amniotic fluid, what diseases are associated with it, and how foods with a high PP/IT profile, including biogenic nutrition, restore metabolomic diversity. The PP/IT profile is a format for representing two independent indices: the density of objects (PP) and the toxicity index (IT). The entry 175/3 means 175 beneficial molecular species and 3 harmful ones per 100 g of product — this is not a fraction, but two independent numbers side by side, like a blood pressure of 120/80. The profile is tied to the vector of product parameters: variety, origin, method of production, condition, freshness, and storage conditions. A monitoring protocol and practical recommendations for late pregnancy are proposed.