Blistering rash in an elderly patient

An 87-year-old man presented with a 6-week history of painful erosions on the left arm and both lower limbs requiring daily wound dressings. Examination showed multiple sharply demarcated, polygonal erosions with a striking geometric configuration. Although the morphology initially suggested traumatic or contact-related injury associated with wound care, direct immunofluorescence of perilesional skin demonstrated linear C3 deposition along the dermoepidermal junction, and serum anti-BP180 antibodies were positive, establishing the diagnosis of bullous pemphigoid. This case highlights that bullous pemphigoid may present predominantly with erosions rather than intact blisters, particularly in older patients undergoing repeated dressings, and emphasizes the importance of direct immunofluorescence when the clinical morphology is atypical.

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Publication Details

Journal
Journal of Hospital Medicine
Published
2026-09-28
DOI
https://doi.org/10.1002/jhm.70494
Primary Topic
Autoimmune Bullous Skin Diseases
Type
article
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article

Blistering rash in an elderly patient

Francisco Nogueira Martins, Francisco Mano, Felicidade Santiago
Journal of Hospital Medicine
Autoimmune Bullous Skin Diseases
article

Blistering rash in an elderly patient

Francisco Nogueira Martins, Francisco Mano, Felicidade Santiago
article en

Abstract

An 87-year-old man presented with a 6-week history of painful erosions on the left arm and both lower limbs requiring daily wound dressings. Examination showed multiple sharply demarcated, polygonal erosions with a striking geometric configuration. Although the morphology initially suggested traumatic or contact-related injury associated with wound care, direct immunofluorescence of perilesional skin demonstrated linear C3 deposition along the dermoepidermal junction, and serum anti-BP180 antibodies were positive, establishing the diagnosis of bullous pemphigoid. This case highlights that bullous pemphigoid may present predominantly with erosions rather than intact blisters, particularly in older patients undergoing repeated dressings, and emphasizes the importance of direct immunofluorescence when the clinical morphology is atypical.

Journal of Hospital Medicine
Hospitais da Universidade de Coimbra (PT)
Sustainable cities and communities
Openalex Percentile: Top 12%
Autoimmune Bullous Skin Diseases
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Blistering rash in an elderly patient — Francisco Nogueira Martins, Francisco Mano, et al. · Journal of Hospital Medicine (2026) | TGRS Research Map | TGRS